U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arl4a ADP-ribosylation factor-like 4A [ Mus musculus (house mouse) ]

Gene ID: 11861, updated on 8-Feb-2024

Summary

Official Symbol
Arl4aprovided by MGI
Official Full Name
ADP-ribosylation factor-like 4Aprovided by MGI
Primary source
MGI:MGI:99437
See related
Ensembl:ENSMUSG00000047446 AllianceGenome:MGI:99437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arl4
Summary
Predicted to enable GTP binding activity. Acts upstream of or within brown fat cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; jaw bone; paraxial mesenchyme; skeletal musculature; and testis. Orthologous to human ARL4A (ADP ribosylation factor like GTPase 4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 30.0), liver E14 (RPKM 10.1) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Arl4a in Genome Data Viewer
Location:
12 B1; 12 18.06 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40083290..40087986, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40033291..40037987, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40399 Neighboring gene ubiquitin specific peptidase 9, X chromosome pseudogene Neighboring gene STARR-seq mESC enhancer starr_31951 Neighboring gene predicted gene, 53717 Neighboring gene STARR-positive B cell enhancer mm9_chr12:40763838-40764139 Neighboring gene STARR-positive B cell enhancer ABC_E7130 Neighboring gene ADP-ribosylation factor-like 4A, opposite strand Neighboring gene scinderin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 4A
Names
ADP-ribosylation factor-like 4
ADP-ribosylation-like 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039515.1NP_001034604.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_001034604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131921, AK048606, CJ164717
    Consensus CDS
    CCDS25890.1
    UniProtKB/Swiss-Prot
    P41275, P61213, Q3TGR5
    Related
    ENSMUSP00000099013.4, ENSMUST00000101472.4
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  2. NM_007487.3NP_031513.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_031513.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC131921, AK048606
    Consensus CDS
    CCDS25890.1
    UniProtKB/Swiss-Prot
    P41275, P61213, Q3TGR5
    Related
    ENSMUSP00000114458.2, ENSMUST00000146905.2
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    40083290..40087986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)