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ARL4A ADP ribosylation factor like GTPase 4A [ Homo sapiens (human) ]

Gene ID: 10124, updated on 1-Jun-2020

Summary

Official Symbol
ARL4Aprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 4Aprovided by HGNC
Primary source
HGNC:HGNC:695
See related
Ensembl:ENSG00000122644 MIM:604786
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL4
Summary
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 32.8), bone marrow (RPKM 17.5) and 24 other tissues See more
Orthologs

Genomic context

See ARL4A in Genome Data Viewer
Location:
7p21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (12686827..12690958)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (12726452..12730559)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375157 Neighboring gene apoptosis-inducing, TAF9-like domain 1 pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr7.1000 Neighboring gene RN7SK pseudogene 228

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 4A
Names
ADP-ribosylation factor-like 4
ADP-ribosylation factor-like 4A
NP_001032241.1
NP_001182325.1
NP_005729.1
NP_997625.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037164.2NP_001032241.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_001032241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC011891, DB472672
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    P40617
    UniProtKB/TrEMBL
    A0A024R9Z2
    Related
    ENSP00000349250.3, ENST00000356797.7
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  2. NM_001195396.1NP_001182325.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_001182325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC011891, AU076407, BQ948724
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    P40617
    UniProtKB/TrEMBL
    A0A024R9Z2
    Related
    ENSP00000385236.1, ENST00000404894.1
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  3. NM_005738.5NP_005729.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_005729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC011891, BQ948724
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    P40617
    UniProtKB/TrEMBL
    A0A024R9Z2
    Related
    ENSP00000498350.1, ENST00000651779.1
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  4. NM_212460.3NP_997625.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_997625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC011891, DB451189
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    P40617
    UniProtKB/TrEMBL
    A0A024R9Z2
    Related
    ENSP00000379899.2, ENST00000396664.2
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    12686827..12690958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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