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Ap2a1 adaptor-related protein complex 2, alpha 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 11771, updated on 5-Apr-2024

Summary

Official Symbol
Ap2a1provided by MGI
Official Full Name
adaptor-related protein complex 2, alpha 1 subunitprovided by MGI
Primary source
MGI:MGI:101921
See related
Ensembl:ENSMUSG00000060279 AllianceGenome:MGI:101921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adtaa
Summary
Enables protein kinase binding activity. Involved in clathrin-dependent endocytosis. Located in filopodium tip. Part of AP-2 adaptor complex. Is expressed in brain; cranial ganglion; dorsal root ganglion; and liver. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 120.3), ovary adult (RPKM 49.1) and 28 other tissues See more
Orthologs
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Genomic context

See Ap2a1 in Genome Data Viewer
Location:
7 B3; 7 29.01 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44549797..44578914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44900373..44929490, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of AP-2 adaptor complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in filopodium tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of membrane coat IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
AP-2 complex subunit alpha-1
Names
100 kDa coated vesicle protein A
adapter-related protein complex 2 alpha-1 subunit
adapter-related protein complex 2 subunit alpha-1
adaptor protein complex AP-2 subunit alpha-1
adaptor protein complex AP-2, alpha 1 subunit
adaptor-related protein complex 2 subunit alpha-1
adaptor-related protein complex AP-2, alpha 1 subunit
alpha-adaptin A
alpha1-adaptin
clathrin assembly protein complex 2 alpha-A large chain
plasma membrane adaptor HA2/AP2 adaptin alpha A subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077264.1NP_001070732.1  AP-2 complex subunit alpha-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AK135424, BC031433, CA327188
    Consensus CDS
    CCDS52238.1
    UniProtKB/Swiss-Prot
    P17426
    Related
    ENSMUSP00000103489.4, ENSMUST00000107857.11
    Conserved Domains (4) summary
    smart00809
    Location:733836
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332355
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:29591
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:842950
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
  2. NM_007458.2NP_031484.1  AP-2 complex subunit alpha-1 isoform a

    See identical proteins and their annotated locations for NP_031484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    BC031433, CA327188
    Consensus CDS
    CCDS52239.1
    UniProtKB/Swiss-Prot
    P17426
    Related
    ENSMUSP00000127842.2, ENSMUST00000166972.9
    Conserved Domains (4) summary
    smart00809
    Location:755858
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332355
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:29591
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:864972
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44549797..44578914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540569.5XP_006540632.1  AP-2 complex subunit alpha-1 isoform X1

    Conserved Domains (3) summary
    smart00809
    Location:679782
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1515
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:788896
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
  2. XM_006540570.1XP_006540633.1  AP-2 complex subunit alpha-1 isoform X2

    Conserved Domains (3) summary
    smart00809
    Location:403506
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1239
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:512620
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain