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Prdx3 peroxiredoxin 3 [ Mus musculus (house mouse) ]

Gene ID: 11757, updated on 31-Jan-2019

Summary

Official Symbol
Prdx3provided by MGI
Official Full Name
peroxiredoxin 3provided by MGI
Primary source
MGI:MGI:88034
See related
Ensembl:ENSMUSG00000024997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aop1; Ef2l; Mer5; Prx3; SP22; TDXM; D0Tohi1; AW822249
Expression
Ubiquitous expression in adrenal adult (RPKM 248.6), heart adult (RPKM 175.6) and 28 other tissues See more
Orthologs

Genomic context

See Prdx3 in Genome Data Viewer
Location:
19 D3; 19 56.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (60864066..60874538, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (60939969..60950441, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 45, member A Neighboring gene sideroflexin 4 Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene predicted gene, 41885 Neighboring gene predicted gene 9529

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
maternal placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-cysteine oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thioredoxin-dependent peroxide reductase, mitochondrial
Names
AOP-1
Prx III
anti-oxidant protein 1
antioxidant protein
mitochondrial Trx dependent peroxide reductase
mitochondrial thioredoxin dependent peroxide reductase
perioredoxin-3
peroxiredoxin III
NP_031478.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007452.2NP_031478.1  thioredoxin-dependent peroxide reductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031478.1

    Status: VALIDATED

    Source sequence(s)
    AK002448, BB372344, BY318475
    Consensus CDS
    CCDS29944.1
    UniProtKB/Swiss-Prot
    P20108
    Related
    ENSMUSP00000025961.6, ENSMUST00000025961.6
    Conserved Domains (2) summary
    PTZ00253
    Location:70252
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:66236
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    60864066..60874538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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