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Prdx3 peroxiredoxin 3 [ Mus musculus (house mouse) ]

Gene ID: 11757, updated on 27-Feb-2024

Summary

Official Symbol
Prdx3provided by MGI
Official Full Name
peroxiredoxin 3provided by MGI
Primary source
MGI:MGI:88034
See related
Ensembl:ENSMUSG00000024997 AllianceGenome:MGI:88034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aop1; Ef2l; Mer5; Prx3; SP22; TDXM; D0Tohi1
Summary
Enables identical protein binding activity. Acts upstream of or within several processes, including maternal placenta development; myeloid cell differentiation; and response to lipopolysaccharide. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Orthologous to human PRDX3 (peroxiredoxin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 248.6), heart adult (RPKM 175.6) and 28 other tissues See more
Orthologs
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Genomic context

See Prdx3 in Genome Data Viewer
Location:
19 D3; 19 56.52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (60852504..60862976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (60864066..60874538, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L26-like Neighboring gene DENN domain containing 10 Neighboring gene sideroflexin 4 Neighboring gene STARR-positive B cell enhancer ABC_E7678 Neighboring gene STARR-positive B cell enhancer ABC_E11681 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965501-60965802 Neighboring gene STARR-positive B cell enhancer mm9_chr19:60965940-60966241 Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene predicted gene 9529 Neighboring gene predicted gene, 22520

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioredoxin peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within maternal placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-cysteine oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thioredoxin-dependent peroxide reductase, mitochondrial
Names
AOP-1
Prx III
anti-oxidant protein 1
mitochondrial Trx dependent peroxide reductase
mitochondrial thioredoxin dependent peroxide reductase
perioredoxin-3
peroxiredoxin III
thioredoxin-dependent peroxiredoxin 3
NP_031478.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007452.2NP_031478.1  thioredoxin-dependent peroxide reductase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_031478.1

    Status: VALIDATED

    Source sequence(s)
    AK002448, BB372344, BY318475
    Consensus CDS
    CCDS29944.1
    UniProtKB/Swiss-Prot
    P20108
    UniProtKB/TrEMBL
    Q8K4K8
    Related
    ENSMUSP00000025961.7, ENSMUST00000025961.7
    Conserved Domains (2) summary
    PTZ00253
    Location:70252
    PTZ00253; tryparedoxin peroxidase; Provisional
    cd03015
    Location:66236
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    60852504..60862976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)