These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_001302272.2 → NP_001289201.1  thioredoxin-dependent peroxide reductase, mitochondrial isoform c precursor

   Status: REVIEWED

   Description

   Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.

   Source sequence(s)

   BC008435, BG282768, BX382389, HY173455

   UniProtKB/Swiss-Prot

   P30048

   Conserved Domains (2) summary

   COG0450
   Location:65 → 186

   AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]

   cd03015
   Location:65 → 186

   PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

2. NM_006793.5 → NP_006784.1  thioredoxin-dependent peroxide reductase, mitochondrial isoform a precursor

   See identical proteins and their annotated locations for NP_006784.1

   Status: REVIEWED

   Description

   Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

   Source sequence(s)

   BC007062, BC008435, CD687044

   Consensus CDS

   CCDS7611.1

   UniProtKB/Swiss-Prot

   B2R7Z0, D3DRC9, E9PH29, P30048, P35690, Q0D2H1, Q13776, Q5T5V2, Q96HK4

   UniProtKB/TrEMBL

   A0A384MTR2, Q53HC2

   Related

   ENSP00000298510.2, ENST00000298510.4

   Conserved Domains (1) summary

   cd03015
   Location:65 → 236

   PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RNA

1. NR_126102.2 RNA Sequence

   Status: REVIEWED

   Description

   Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   AV761690, BC008435, CD687044, HY173455

2. NR_126103.2 RNA Sequence

   Status: REVIEWED

   Description

   Transcript Variant: This variant (5) lacks two alternate exons in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   BC008435, BG115645, CD687044, HY173455

3. NR_126105.2 RNA Sequence

   Status: REVIEWED

   Description

   Transcript Variant: This variant (6) uses two alternate splice sites and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   BC008435, BF209381, CD687044, HY173455

4. NR_126106.2 RNA Sequence

   Status: REVIEWED

   Description

   Transcript Variant: This variant (7) uses two alternate splice sites and lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

   Source sequence(s)

   BC008435, HY082255

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

   Range

   119167720..119178812 complement

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

1. NC_060934.1 Alternate T2T-CHM13v2.0

   Range

   120063136..120074228 complement

   Download

   GenBank, FASTA, Sequence Viewer (Graphics)

The following Reference Sequences have been suppressed. Explain

These RefSeqs were suppressed for the cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links, or BLAST links (BLink), but may still be retrieved by clicking on their accession.version below.

1. NM_014098.3: Suppressed sequence

   Description

   NM_014098.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript contains unsupported non-consensus splice sites.