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PRDX3 peroxiredoxin 3 [ Homo sapiens (human) ]

Gene ID: 10935, updated on 6-Jul-2025
Official Symbol
PRDX3provided by HGNC
Official Full Name
peroxiredoxin 3provided by HGNC
Primary source
HGNC:HGNC:9354
See related
Ensembl:ENSG00000165672 MIM:604769; AllianceGenome:HGNC:9354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AOP1; MER5; AOP-1; PPPCD; SP-22; HBC189; SCAR32; PRO1748; prx-III
Summary
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in adrenal (RPKM 195.5), kidney (RPKM 144.1) and 25 other tissues See more
Orthologs
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See PRDX3 in Genome Data Viewer
Location:
10q26.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119167720..119178812, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120063136..120074228, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120927232..120938324, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120865335-120865834 Neighboring gene Sharpr-MPRA regulatory region 2644 Neighboring gene DENN domain containing 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120901959-120902460 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:120924677-120924863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2869 Neighboring gene sideroflexin 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120937203-120937847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2870 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120942385-120943130 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10037 Neighboring gene Sharpr-MPRA regulatory region 12134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4105 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2873 Neighboring gene GRK5 intronic transcript 1 Neighboring gene RNA, 7SL, cytoplasmic 749, pseudogene Neighboring gene G protein-coupled receptor kinase 5

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of peroxiredoxin 3 (PRDX3; PRO1748) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of peroxiredoxin 1, 3, and 4 proteins in umbilical cord blood mononuclear cells and T-cell lines PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC24293, MGC104387

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADH-dependent peroxiredoxin activity NAS
Non-traceable Author Statement
more info
PubMed 
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thioredoxin peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
thioredoxin-dependent peroxide reductase, mitochondrial
Names
antioxidant protein 1
epididymis secretory sperm binding protein
peroxiredoxin III
protein MER5 homolog
thioredoxin-dependent peroxiredoxin 3
NP_001289201.1
NP_006784.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302272.2NP_001289201.1  thioredoxin-dependent peroxide reductase, mitochondrial isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    BC008435, BG282768, BX382389, HY173455
    UniProtKB/Swiss-Prot
    P30048
    Conserved Domains (2) summary
    COG0450
    Location:65186
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03015
    Location:65186
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
  2. NM_006793.5NP_006784.1  thioredoxin-dependent peroxide reductase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_006784.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC007062, BC008435, CD687044
    Consensus CDS
    CCDS7611.1
    UniProtKB/Swiss-Prot
    B2R7Z0, D3DRC9, E9PH29, P30048, P35690, Q0D2H1, Q13776, Q5T5V2, Q96HK4
    UniProtKB/TrEMBL
    A0A384MTR2, Q53HC2
    Related
    ENSP00000298510.2, ENST00000298510.4
    Conserved Domains (1) summary
    cd03015
    Location:65236
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

RNA

  1. NR_126102.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AV761690, BC008435, CD687044, HY173455
  2. NR_126103.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC008435, BG115645, CD687044, HY173455
  3. NR_126105.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two alternate splice sites and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC008435, BF209381, CD687044, HY173455
  4. NR_126106.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses two alternate splice sites and lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC008435, HY082255

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119167720..119178812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    120063136..120074228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014098.3: Suppressed sequence

    Description
    NM_014098.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript contains unsupported non-consensus splice sites.