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Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [ Mus musculus (house mouse) ]

Gene ID: 11739, updated on 27-Feb-2024

Summary

Official Symbol
Slc25a4provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4provided by MGI
Primary source
MGI:MGI:1353495
See related
Ensembl:ENSMUSG00000031633 AllianceGenome:MGI:1353495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ant1; mANC1
Summary
Enables ATP:ADP antiporter activity; oxidative phosphorylation uncoupler activity; and proton transmembrane transporter activity. Involved in several processes, including adenine nucleotide transport; positive regulation of mitophagy; and regulation of mitochondrial membrane permeability. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial inner membrane and myelin sheath. Part of mitochondrial permeability transition pore complex. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 2616.6), cerebellum adult (RPKM 363.2) and 16 other tissues See more
Orthologs
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Genomic context

See Slc25a4 in Genome Data Viewer
Location:
8 B1.1; 8 26.22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46660205..46664099, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46207168..46211062, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene sorting nexin 25 Neighboring gene STARR-positive B cell enhancer ABC_E10497 Neighboring gene predicted gene 15634 Neighboring gene cilia and flagella associated protein 97 Neighboring gene STARR-positive B cell enhancer ABC_E10498 Neighboring gene actin, gamma, pseudogene 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP:ADP antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP:ADP antiporter activity ISO
Inferred from Sequence Orthology
more info
 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidative phosphorylation uncoupler activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables proton transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ADP transport ISO
Inferred from Sequence Orthology
more info
 
involved_in adaptive thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic mitochondrial changes IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitochondrial ADP transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial ADP transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial ADP transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial ATP transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial ATP transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial ATP transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrial membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of mitochondrial permeability transition pore complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
ADP/ATP translocase 1
Names
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart/skeletal muscle
ANT 1
adenine nucleotide translocase-1
adenine nucleotide translocator 1, skeletal muscle
solute carrier family 25 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007450.5NP_031476.3  ADP/ATP translocase 1

    See identical proteins and their annotated locations for NP_031476.3

    Status: VALIDATED

    Source sequence(s)
    AC156551
    Consensus CDS
    CCDS40333.1
    UniProtKB/Swiss-Prot
    P48962, Q62164
    UniProtKB/TrEMBL
    Q8BVI9
    Related
    ENSMUSP00000034049.5, ENSMUST00000034049.5
    Conserved Domains (1) summary
    PTZ00169
    Location:2298
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    46660205..46664099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)