Format

Send to:

Choose Destination

CIB3 calcium and integrin binding family member 3 [ Homo sapiens (human) ]

Gene ID: 117286, updated on 23-Nov-2021

Summary

Official Symbol
CIB3provided by HGNC
Official Full Name
calcium and integrin binding family member 3provided by HGNC
Primary source
HGNC:HGNC:24580
See related
Ensembl:ENSG00000141977 MIM:610645
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIP3
Summary
This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CIB3 in Genome Data Viewer
Location:
19p13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (16161368..16173525, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16272179..16284336, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6392 Neighboring gene tropomyosin 4 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene hematopoietic SH2 domain containing Neighboring gene family with sequence similarity 32 member A Neighboring gene adaptor related protein complex 1 subunit mu 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC96922, MGC138405, MGC142151

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
calcium and integrin-binding family member 3
Names
DNA-dependent protein kinase catalytic subunit-interacting protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300922.2NP_001287851.1  calcium and integrin-binding family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive alternate exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AB050868, AW295492, BC069428, BC112200
    Consensus CDS
    CCDS74305.1
    UniProtKB/Swiss-Prot
    Q96Q77
    Related
    ENSP00000369188.3, ENST00000379859.7
    Conserved Domains (2) summary
    pfam13499
    Location:59124
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:62124
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_054113.4NP_473454.1  calcium and integrin-binding family member 3 isoform 1

    See identical proteins and their annotated locations for NP_473454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB050868, AW295492, BC112200
    Consensus CDS
    CCDS12340.1
    UniProtKB/Swiss-Prot
    Q96Q77
    Related
    ENSP00000269878.3, ENST00000269878.8
    Conserved Domains (2) summary
    COG5126
    Location:20178
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:111173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    16161368..16173525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center