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THEM4 thioesterase superfamily member 4 [ Homo sapiens (human) ]

Gene ID: 117145, updated on 2-Mar-2021

Summary

Official Symbol
THEM4provided by HGNC
Official Full Name
thioesterase superfamily member 4provided by HGNC
Primary source
HGNC:HGNC:17947
See related
Ensembl:ENSG00000159445 MIM:606388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTMP
Summary
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 4.4), testis (RPKM 3.1) and 25 other tissues See more
Orthologs
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Genomic context

See THEM4 in Genome Data Viewer
Location:
1q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151870866..151909511, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151843342..151881987, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene C2CD4D and THEM5 antisense RNA 1 Neighboring gene C2 calcium dependent domain containing 4D Neighboring gene thioesterase superfamily member 5 Neighboring gene keratin 8 pseudogene 28 Neighboring gene uncharacterized LOC105371441 Neighboring gene S100 calcium binding protein A10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Genetic determinants influencing human serum metabolome among African Americans.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27206, MGC29636

Gene Ontology Provided by GOA

Function Evidence Code Pubs
myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase THEM4
Names
C-terminal modulator protein
acyl-CoA thioesterase THEM4
carboxyl-terminal modulator protein
NP_444283.2
XP_011507444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053055.5NP_444283.2  acyl-coenzyme A thioesterase THEM4

    See identical proteins and their annotated locations for NP_444283.2

    Status: REVIEWED

    Source sequence(s)
    AF075119, AJ313515, AL450992, DC353229
    Consensus CDS
    CCDS1006.1
    UniProtKB/Swiss-Prot
    Q5T1C6
    UniProtKB/TrEMBL
    A8K0C9
    Related
    ENSP00000357804.3, ENST00000368814.8
    Conserved Domains (1) summary
    cd03443
    Location:119231
    PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151870866..151909511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509142.2XP_011507444.1  acyl-coenzyme A thioesterase THEM4 isoform X1

    Conserved Domains (1) summary
    cd03443
    Location:55167
    PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176853.2: Suppressed sequence

    Description
    NM_176853.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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