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ART5 ADP-ribosyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 116969, updated on 7-Oct-2019

Summary

Official Symbol
ART5provided by HGNC
Official Full Name
ADP-ribosyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:24049
See related
Ensembl:ENSG00000167311 MIM:610625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTC5
Summary
The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Biased expression in testis (RPKM 6.5), ovary (RPKM 2.3) and 5 other tissues See more
Orthologs

Genomic context

See ART5 in Genome Data Viewer
Location:
11p15.4
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (3638503..3642392, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3659733..3663546, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 117 pseudogene Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC22848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
peptidyl-arginine ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ecto-ADP-ribosyltransferase 5
Names
ADP-ribosyltransferase C2 and C3 toxin-like 5
NAD(P)(+)--arginine ADP-ribosyltransferase 5
mono(ADP-ribosyl)transferase 5
NP_001073004.1
NP_001284597.1
NP_443750.2
XP_005252836.1
XP_006718199.1
XP_011518181.1
XP_016872660.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079536.1NP_001073004.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_001073004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 5' UTR compared to transcript variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC060812, AW241897, CD557970, Y16835
    Consensus CDS
    CCDS7743.1
    UniProtKB/Swiss-Prot
    Q96L15
    Related
    ENSP00000352992.4, ENST00000359918.8
    Conserved Domains (1) summary
    pfam01129
    Location:28254
    ART; NAD:arginine ADP-ribosyltransferase
  2. NM_001297668.2NP_001284597.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon and an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC060812, AY358466
    Consensus CDS
    CCDS73242.1
    UniProtKB/Swiss-Prot
    Q96L15
    Related
    ENSP00000380257.3, ENST00000397067.7
    Conserved Domains (1) summary
    cl00173
    Location:28196
    VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  3. NM_053017.5NP_443750.2  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_443750.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC060812, BC014577
    Consensus CDS
    CCDS7743.1
    UniProtKB/Swiss-Prot
    Q96L15
    Related
    ENSP00000380258.3, ENST00000397068.8
    Conserved Domains (1) summary
    pfam01129
    Location:28254
    ART; NAD:arginine ADP-ribosyltransferase

RNA

  1. NR_123732.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and and alternate splice junction at the 5' end of the second exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC060812, BC014577, HY018364

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    3638503..3642392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017171.1XP_016872660.1  ecto-ADP-ribosyltransferase 5 isoform X3

  2. XM_011519879.3XP_011518181.1  ecto-ADP-ribosyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_011518181.1

    Conserved Domains (1) summary
    pfam01129
    Location:28254
    ART; NAD:arginine ADP-ribosyltransferase
  3. XM_006718136.4XP_006718199.1  ecto-ADP-ribosyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006718199.1

    Conserved Domains (1) summary
    pfam01129
    Location:28254
    ART; NAD:arginine ADP-ribosyltransferase
  4. XM_005252779.3XP_005252836.1  ecto-ADP-ribosyltransferase 5 isoform X2

    Related
    ENSP00000402737.2, ENST00000453353.2
    Conserved Domains (1) summary
    pfam01129
    Location:28254
    ART; NAD:arginine ADP-ribosyltransferase
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