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Art5 ADP-ribosyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 11875, updated on 9-Nov-2022

Summary

Official Symbol
Art5provided by MGI
Official Full Name
ADP-ribosyltransferase 5provided by MGI
Primary source
MGI:MGI:107948
See related
Ensembl:ENSMUSG00000070424 AllianceGenome:MGI:107948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTC5; Yac-2
Summary
Enables NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. Acts upstream of or within protein ADP-ribosylation. Located in extracellular region and membrane. Is expressed in several structures, including heart; limb; male reproductive system; nose; and skeletal musculature. Orthologous to human ART5 (ADP-ribosyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 21.8), heart adult (RPKM 3.7) and 1 other tissue See more
Orthologs
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Genomic context

See Art5 in Genome Data Viewer
Location:
7 E2; 7 54.71 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101746086..101750466, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102096879..102100291, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene nucleoporin 98 Neighboring gene post-GPI attachment to proteins 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC151200, MGC151226

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ecto-ADP-ribosyltransferase 5
Names
ADP-ribosyltransferase C2 and C3 toxin-like 5
NAD(P)(+)--arginine ADP-ribosyltransferase 5
mono(ADP-ribosyl)transferase 5
NP_001278283.1
NP_031517.2
XP_006507321.1
XP_006507322.1
XP_006507323.1
XP_006507324.1
XP_006507325.1
XP_006507326.1
XP_030097883.1
XP_030097884.1
XP_030097885.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291354.2NP_001278283.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_001278283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC132297
    Consensus CDS
    CCDS21525.1
    UniProtKB/Swiss-Prot
    P70352, Q921A5
    UniProtKB/TrEMBL
    Q3V0V9
    Conserved Domains (1) summary
    pfam01129
    Location:29255
    ART; NAD:arginine ADP-ribosyltransferase
  2. NM_001411985.1NP_001398914.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/Swiss-Prot
    Q921A5
  3. NM_001411986.1NP_001398915.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
  4. NM_001411987.1NP_001398916.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
  5. NM_001411988.1NP_001398917.1  ecto-ADP-ribosyltransferase 5 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/TrEMBL
    A0A8C6GAG1
  6. NM_001411989.1NP_001398918.1  ecto-ADP-ribosyltransferase 5 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/TrEMBL
    A0A8C6GAG1
  7. NM_001411990.1NP_001398919.1  ecto-ADP-ribosyltransferase 5 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
  8. NM_001411991.1NP_001398920.1  ecto-ADP-ribosyltransferase 5 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/TrEMBL
    B7ZMV7
  9. NM_001411992.1NP_001398921.1  ecto-ADP-ribosyltransferase 5 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/TrEMBL
    B7ZMV7
  10. NM_007491.3NP_031517.2  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_031517.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC132297
    Consensus CDS
    CCDS21525.1
    UniProtKB/Swiss-Prot
    P70352, Q921A5
    UniProtKB/TrEMBL
    Q14AG6, Q3V0V9
    Related
    ENSMUSP00000102550.2, ENSMUST00000106937.8
    Conserved Domains (1) summary
    pfam01129
    Location:29255
    ART; NAD:arginine ADP-ribosyltransferase

RNA

  1. NR_111935.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon and lacks an alternate internal segment compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132297

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101746086..101750466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507258.5XP_006507321.1  ecto-ADP-ribosyltransferase 5 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29255
    ART; NAD:arginine ADP-ribosyltransferase
  2. XM_030242023.2XP_030097883.1  ecto-ADP-ribosyltransferase 5 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29255
    ART; NAD:arginine ADP-ribosyltransferase
  3. XM_006507260.4XP_006507323.1  ecto-ADP-ribosyltransferase 5 isoform X2

    UniProtKB/Swiss-Prot
    P70352
    Related
    ENSMUSP00000102547.2, ENSMUST00000106934.2
    Conserved Domains (1) summary
    cl00173
    Location:29157
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  4. XM_006507259.5XP_006507322.1  ecto-ADP-ribosyltransferase 5 isoform X2

    UniProtKB/Swiss-Prot
    P70352
    Conserved Domains (1) summary
    cl00173
    Location:29157
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  5. XM_030242024.2XP_030097884.1  ecto-ADP-ribosyltransferase 5 isoform X3

    Conserved Domains (1) summary
    cl00173
    Location:29151
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  6. XM_030242025.2XP_030097885.1  ecto-ADP-ribosyltransferase 5 isoform X4

    Related
    ENSMUSP00000102548.2, ENSMUST00000106935.8
    Conserved Domains (1) summary
    cl00173
    Location:29122
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  7. XM_006507261.5XP_006507324.1  ecto-ADP-ribosyltransferase 5 isoform X4

    UniProtKB/TrEMBL
    B7ZMV7
    Conserved Domains (1) summary
    cl00173
    Location:29122
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  8. XM_006507263.5XP_006507326.1  ecto-ADP-ribosyltransferase 5 isoform X6

    See identical proteins and their annotated locations for XP_006507326.1

    UniProtKB/Swiss-Prot
    P70352
    Conserved Domains (1) summary
    cl00173
    Location:29119
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
  9. XM_006507262.4XP_006507325.1  ecto-ADP-ribosyltransferase 5 isoform X5

    Conserved Domains (1) summary
    cl00173
    Location:29160
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...