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Tgs1 trimethylguanosine synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 116940, updated on 2-Oct-2018

Summary

Official Symbol
Tgs1provided by MGI
Official Full Name
trimethylguanosine synthase 1provided by MGI
Primary source
MGI:MGI:2151797
See related
Ensembl:ENSMUSG00000028233 Vega:OTTMUSG00000004256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pimt; Ncoa6ip; D4Ertd800e
Expression
Broad expression in CNS E11.5 (RPKM 11.1), CNS E14 (RPKM 7.8) and 22 other tissues See more
Orthologs

Genomic context

See Tgs1 in Genome Data Viewer
Location:
4 A1; 4 1.99 cM
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (3574879..3616624)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (3502026..3543771)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene microRNA 3471-2 Neighboring gene transmembrane protein 68 Neighboring gene RIKEN cDNA 2210414B05 gene Neighboring gene predicted gene, 42250 Neighboring gene LYN proto-oncogene, Src family tyrosine kinase Neighboring gene RIKEN cDNA 6330407A03 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA trimethylguanosine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA trimethylguanosine synthase activity ISO
Inferred from Sequence Orthology
more info
 
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
7-methylguanosine RNA capping IEA
Inferred from Electronic Annotation
more info
 
7-methylguanosine cap hypermethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
7-methylguanosine cap hypermethylation ISO
Inferred from Sequence Orthology
more info
 
RNA methylation IEA
Inferred from Electronic Annotation
more info
 
methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
trimethylguanosine synthase
Names
PIPMT
PRIP-interacting protein with methyltransferase motif
nuclear receptor coactivator 6-interacting protein
trimethylguanosine synthase homolog
NP_473430.3
XP_006537621.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054089.4NP_473430.3  trimethylguanosine synthase

    See identical proteins and their annotated locations for NP_473430.3

    Status: VALIDATED

    Source sequence(s)
    AK044895, BC075728
    Consensus CDS
    CCDS17938.1
    UniProtKB/Swiss-Prot
    Q923W1
    Related
    ENSMUSP00000054112.5, OTTMUSP00000004654, ENSMUST00000052712.5, OTTMUST00000009636
    Conserved Domains (1) summary
    pfam09445
    Location:683835
    Methyltransf_15; RNA cap guanine-N2 methyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    3574879..3616624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537558.2XP_006537621.1  trimethylguanosine synthase isoform X1

    Conserved Domains (1) summary
    pfam09445
    Location:594746
    Methyltransf_15; RNA cap guanine-N2 methyltransferase
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