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TGS1 trimethylguanosine synthase 1 [ Homo sapiens (human) ]

Gene ID: 96764, updated on 8-Jul-2021

Summary

Official Symbol
TGS1provided by HGNC
Official Full Name
trimethylguanosine synthase 1provided by HGNC
Primary source
HGNC:HGNC:17843
See related
Ensembl:ENSG00000137574 MIM:606461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIMT; PIPMT; NCOA6IP
Expression
Ubiquitous expression in lymph node (RPKM 6.7), appendix (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See TGS1 in Genome Data Viewer
Location:
8q12.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (55773446..55826445)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (56686005..56739004)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375846 Neighboring gene RNA, 5S ribosomal pseudogene 265 Neighboring gene transmembrane protein 68 Neighboring gene CRISPRi-validated cis-regulatory element chr8.1663 Neighboring gene LYN proto-oncogene, Src family tyrosine kinase Neighboring gene small nucleolar RNA, H/ACA box 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
GeneReviews: Not available
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag PIMT (peroxisome proliferator-activated receptor-interacting protein with methyltransferase) protein enhances the expression of HIV-1 Gag, CA and RT PubMed
Rev rev PIMT associates with Gag-Pol-RRE RNA in the presence of HIV-1 Rev, suggesting PIMT selectively modulates the expression of Rev/RRE-dependent RNAs PubMed
capsid gag PIMT (peroxisome proliferator-activated receptor-interacting protein with methyltransferase) protein enhances the expression of HIV-1 Gag, CA and RT PubMed
reverse transcriptase gag-pol PIMT (peroxisome proliferator-activated receptor-interacting protein with methyltransferase) protein enhances the expression of HIV-1 Gag, CA and RT PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22995, DKFZp762A163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA methyltransferase activity TAS
Traceable Author Statement
more info
 
enables RNA trimethylguanosine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA trimethylguanosine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of small nuclear ribonucleoprotein complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
trimethylguanosine synthase
Names
CLL-associated antigen KW-2
PRIP-interacting protein with methyltransferase motif
cap-specific guanine-N2 methyltransferase
hepatocellular carcinoma-associated antigen 137
nuclear receptor coactivator 6-interacting protein
NP_001304831.1
NP_001350113.1
NP_079107.6
XP_006716548.1
XP_016869493.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317902.2NP_001304831.1  trimethylguanosine synthase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences compared to variant 1. These differences result in the use of a downstream translation start site, a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC018607, AC100817, AF286340, BX648548
    UniProtKB/Swiss-Prot
    Q96RS0
    Conserved Domains (1) summary
    cl17173
    Location:598621
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001363184.2NP_001350113.1  trimethylguanosine synthase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018607, AF286340, AF432215, BM853546, DA456243, DB082992
    Conserved Domains (1) summary
    pfam09445
    Location:598750
    Methyltransf_15; RNA cap guanine-N2 methyltransferase
  3. NM_024831.8NP_079107.6  trimethylguanosine synthase isoform 1

    See identical proteins and their annotated locations for NP_079107.6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC018607, AF286340, AF432215, BM853546, DB082992
    Consensus CDS
    CCDS34894.1
    UniProtKB/Swiss-Prot
    Q96RS0
    Related
    ENSP00000260129.5, ENST00000260129.6
    Conserved Domains (1) summary
    pfam09445
    Location:691843
    Methyltransf_15; RNA cap guanine-N2 methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    55773446..55826445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716485.2XP_006716548.1  trimethylguanosine synthase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:691714
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017014004.1XP_016869493.1  trimethylguanosine synthase isoform X3

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