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Mta1 metastasis associated 1 [ Mus musculus (house mouse) ]

Gene ID: 116870, updated on 5-Mar-2024

Summary

Official Symbol
Mta1provided by MGI
Official Full Name
metastasis associated 1provided by MGI
Primary source
MGI:MGI:2150037
See related
Ensembl:ENSMUSG00000021144 AllianceGenome:MGI:2150037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in cytoplasm and nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and long bone epiphysis. Orthologous to human MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 62.3), adrenal adult (RPKM 52.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mta1 in Genome Data Viewer
Location:
12 F1; 12 61.57 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113061830..113100826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113098248..113137206)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114285178-114285287 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:114285299-114285486 Neighboring gene testis expressed gene 22 Neighboring gene RIKEN cDNA F930026P19 gene Neighboring gene cysteine rich protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118456

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell fate specification NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of stem cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in secretory granule organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuRD complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metastasis-associated protein MTA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346696.1NP_001333625.1  metastasis-associated protein MTA1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB794096, AC073562, BU053969
    Consensus CDS
    CCDS84004.1
    UniProtKB/TrEMBL
    E9PX23, M1VB37
    Related
    ENSMUSP00000105349.3, ENSMUST00000109727.9
  2. NM_001364620.1NP_001351549.1  metastasis-associated protein MTA1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB794101, AC073562
    UniProtKB/TrEMBL
    M1VB37, M1VMF6
    Conserved Domains (4) summary
    cd11661
    Location:287332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:388441
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3188
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:167219
    ELM2; ELM2 domain
  3. NM_001364621.1NP_001351550.1  metastasis-associated protein MTA1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC073562
    UniProtKB/Swiss-Prot
    Q80UI1, Q8K4B0, Q8K4D4, Q924K9
    UniProtKB/TrEMBL
    M1VB37, M1VHG1
    Related
    ENSMUSP00000009099.7, ENSMUST00000009099.13
    Conserved Domains (4) summary
    cd11661
    Location:287332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:388441
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3188
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:167219
    ELM2; ELM2 domain
  4. NM_001364622.1NP_001351551.1  metastasis-associated protein MTA1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073562
    UniProtKB/TrEMBL
    M1VB37, M1VHG6
    Conserved Domains (4) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:371424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150202
    ELM2; ELM2 domain
  5. NM_001364623.1NP_001351552.1  metastasis-associated protein MTA1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC073562
    UniProtKB/TrEMBL
    M1VB37, M1VHG3
    Conserved Domains (4) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:371424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150202
    ELM2; ELM2 domain
  6. NM_054081.2NP_473422.2  metastasis-associated protein MTA1 isoform 1

    See identical proteins and their annotated locations for NP_473422.2

    Status: VALIDATED

    Source sequence(s)
    AC073562, BC112910, CF171555, CJ139622, CX203022, CX213009
    Consensus CDS
    CCDS36574.1
    UniProtKB/TrEMBL
    F8WHY8, M1VB37
    Related
    ENSMUSP00000105348.2, ENSMUST00000109726.8
    Conserved Domains (6) summary
    smart00717
    Location:269316
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:371424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd00202
    Location:375431
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    cd04709
    Location:3171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150202
    ELM2; ELM2 domain

RNA

  1. NR_157248.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073562
  2. NR_157249.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073562
  3. NR_157250.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073562
  4. NR_157251.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073562
  5. NR_186595.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073562

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113061830..113100826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515418.3XP_006515481.1  metastasis-associated protein MTA1 isoform X1

    See identical proteins and their annotated locations for XP_006515481.1

    UniProtKB/TrEMBL
    M1VB37
    Conserved Domains (5) summary
    cd11661
    Location:287332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:388441
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3188
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:167219
    ELM2; ELM2 domain
    pfam17226
    Location:464541
    MTA_R1; MTA R1 domain
  2. XM_006515420.3XP_006515483.1  metastasis-associated protein MTA1 isoform X2

    See identical proteins and their annotated locations for XP_006515483.1

    UniProtKB/TrEMBL
    M1VB37
    Conserved Domains (5) summary
    cd11661
    Location:287332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:388441
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3188
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:167219
    ELM2; ELM2 domain
    pfam17226
    Location:464541
    MTA_R1; MTA R1 domain
  3. XM_006515425.3XP_006515488.1  metastasis-associated protein MTA1 isoform X5

    See identical proteins and their annotated locations for XP_006515488.1

    UniProtKB/TrEMBL
    M1VB37
    Conserved Domains (5) summary
    cd11661
    Location:287332
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:388441
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3188
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:167219
    ELM2; ELM2 domain
    pfam17226
    Location:464541
    MTA_R1; MTA R1 domain
  4. XM_006515421.3XP_006515484.1  metastasis-associated protein MTA1 isoform X3

    See identical proteins and their annotated locations for XP_006515484.1

    UniProtKB/TrEMBL
    M1VB37
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:371424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150202
    ELM2; ELM2 domain
    pfam17226
    Location:447524
    MTA_R1; MTA R1 domain
  5. XM_036157169.1XP_036013062.1  metastasis-associated protein MTA1 isoform X4

    UniProtKB/TrEMBL
    M1VB37
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:371424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3171
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150202
    ELM2; ELM2 domain
    pfam17226
    Location:447524
    MTA_R1; MTA R1 domain
  6. XM_030246531.1XP_030102391.1  metastasis-associated protein MTA1 isoform X6

    UniProtKB/TrEMBL
    M1VB37
    Conserved Domains (5) summary
    cd11661
    Location:196241
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:297350
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cl02608
    Location:197
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
    pfam01448
    Location:76128
    ELM2; ELM2 domain
    pfam17226
    Location:373450
    MTA_R1; MTA R1 domain
  7. XM_011243988.1XP_011242290.1  metastasis-associated protein MTA1 isoform X7

    See identical proteins and their annotated locations for XP_011242290.1

    UniProtKB/TrEMBL
    M1VB37
    Conserved Domains (5) summary
    cd11661
    Location:268313
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:369422
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:8169
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:148200
    ELM2; ELM2 domain
    pfam17226
    Location:445522
    MTA_R1; MTA R1 domain

RNA

  1. XR_003949980.2 RNA Sequence

  2. XR_001780412.3 RNA Sequence

    Related
    ENSMUST00000130926.8
  3. XR_004937406.1 RNA Sequence