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Alox15 arachidonate 15-lipoxygenase [ Mus musculus (house mouse) ]

Gene ID: 11687, updated on 27-Feb-2024

Summary

Official Symbol
Alox15provided by MGI
Official Full Name
arachidonate 15-lipoxygenaseprovided by MGI
Primary source
MGI:MGI:87997
See related
Ensembl:ENSMUSG00000018924 AllianceGenome:MGI:87997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
12-LO; 15-LOX; L-12LO; Alox12l; 12/15-LO
Summary
Enables arachidonate 12(S)-lipoxygenase activity and arachidonate 15-lipoxygenase activity. Involved in several processes, including fatty acid metabolic process; phosphatidylethanolamine biosynthetic process; and positive regulation of actin filament polymerization. Acts upstream of or within bone mineralization. Located in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; liver; nose; peritoneal fluid; and respiratory system. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 3.1), ovary adult (RPKM 2.5) and 24 other tissues See more
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Genomic context

See Alox15 in Genome Data Viewer
Location:
11 B3; 11 42.99 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70234973..70279465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70344147..70390538, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40192 Neighboring gene arachidonate lipoxygenase, epidermal Neighboring gene STARR-seq mESC enhancer starr_29874 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29875 Neighboring gene STARR-seq mESC enhancer starr_29876 Neighboring gene proline, glutamic acid and leucine rich protein 1 Neighboring gene predicted gene 12313

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate 12(S)-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arachidonate 12(S)-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate 12(S)-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonate 15-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate 15-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables hepoxilin A3 synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables hepoxilin-epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables linoleate 13S-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-13 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in lipoxin A4 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipoxygenase pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylethanolamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX15
Names
12-LOX
12/15-lipoxygenase
arachidonate 12-lipoxygenase, leukocyte-type
arachidonate omega-6 lipoxygenase
hepoxilin A3 synthase Alox15
linoleate 13S-lipoxygenase
NP_033790.3
XP_006532099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009660.3NP_033790.3  polyunsaturated fatty acid lipoxygenase ALOX15

    See identical proteins and their annotated locations for NP_033790.3

    Status: VALIDATED

    Source sequence(s)
    AK142371, AL596096, U04331
    Consensus CDS
    CCDS24944.1
    UniProtKB/Swiss-Prot
    P39654, Q4FJY9, Q5F2E3, Q6PHB2
    UniProtKB/TrEMBL
    A2CF88
    Related
    ENSMUSP00000019068.7, ENSMUST00000019068.7
    Conserved Domains (2) summary
    cd01753
    Location:2112
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:202654
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70234973..70279465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532036.5XP_006532099.1  polyunsaturated fatty acid lipoxygenase ALOX15 isoform X1

    See identical proteins and their annotated locations for XP_006532099.1

    Conserved Domains (2) summary
    cd01753
    Location:32142
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232684
    Lipoxygenase