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Alox15 arachidonate 15-lipoxygenase [ Mus musculus (house mouse) ]

Gene ID: 11687, updated on 24-Apr-2018
Official Symbol
Alox15provided by MGI
Official Full Name
arachidonate 15-lipoxygenaseprovided by MGI
Primary source
MGI:MGI:87997
See related
Ensembl:ENSMUSG00000018924 Vega:OTTMUSG00000006044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
12-LO; 15-LOX; L-12LO; Alox12l; 12/15-LO
Expression
Broad expression in subcutaneous fat pad adult (RPKM 3.1), ovary adult (RPKM 2.5) and 24 other tissues See more
See Alox15 in Genome Data Viewer
Location:
11 B3; 11 42.99 cM
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (70344147..70382635, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70157649..70165533, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40192 Neighboring gene arachidonate lipoxygenase, epidermal Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene proline, glutamic acid and leucine rich protein 1 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
arachidonate 12-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 12-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
arachidonate 15-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonate 15-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
hepoxilin A3 synthase activity ISO
Inferred from Sequence Orthology
more info
 
hepoxilin-epoxide hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-13 ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipoxin A4 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
lipoxygenase pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylethanolamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
regulation of engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
lipid droplet ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
arachidonate 15-lipoxygenase
Names
12-LOX
12/15-lipoxygenase
arachidonate 12-lipoxygenase, leukocyte-type
arachidonate omega-6 lipoxygenase
NP_033790.3
XP_006532099.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009660.3NP_033790.3  arachidonate 15-lipoxygenase

    See identical proteins and their annotated locations for NP_033790.3

    Status: VALIDATED

    Source sequence(s)
    AK142371, AL596096, U04331
    Consensus CDS
    CCDS24944.1
    UniProtKB/Swiss-Prot
    P39654
    UniProtKB/TrEMBL
    A2CF88
    Related
    ENSMUSP00000019068.6, OTTMUSP00000006312, ENSMUST00000019068.6, OTTMUST00000013609
    Conserved Domains (2) summary
    cd01753
    Location:2112
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:202654
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    70344147..70382635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532036.3XP_006532099.1  arachidonate 15-lipoxygenase isoform X1

    See identical proteins and their annotated locations for XP_006532099.1

    Conserved Domains (2) summary
    cd01753
    Location:32142
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:232684
    Lipoxygenase; Lipoxygenase

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    448640..456524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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