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HSPA12B heat shock protein family A (Hsp70) member 12B [ Homo sapiens (human) ]

Gene ID: 116835, updated on 23-Nov-2021

Summary

Official Symbol
HSPA12Bprovided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 12Bprovided by HGNC
Primary source
HGNC:HGNC:16193
See related
Ensembl:ENSG00000132622 MIM:610702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf60
Summary
The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Broad expression in fat (RPKM 15.5), spleen (RPKM 11.6) and 19 other tissues See more
Orthologs
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Genomic context

See HSPA12B in Genome Data Viewer
Location:
20p13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3732685..3753111)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3713332..3733758)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 33 Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene Sharpr-MPRA regulatory region 3812 Neighboring gene chromosome 20 open reading frame 27 Neighboring gene Sharpr-MPRA regulatory region 2213 Neighboring gene sperm flagellar 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32150, MGC131912, dJ1009E24.2

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
heat shock 70 kDa protein 12B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197327.2NP_001184256.1  heat shock 70 kDa protein 12B isoform 2

    See identical proteins and their annotated locations for NP_001184256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL109804, BC110881, BC117284, BC143932
    UniProtKB/Swiss-Prot
    Q96MM6
    UniProtKB/TrEMBL
    B7ZLP2
    Conserved Domains (1) summary
    cl17037
    Location:61528
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  2. NM_001318322.2NP_001305251.1  heat shock 70 kDa protein 12B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK297120, AL109804, BC090857
    Consensus CDS
    CCDS82596.1
    UniProtKB/TrEMBL
    B4DLR4, Q5BKZ8, Q5JX83
    Related
    ENSP00000382608.1, ENST00000399701.1
    Conserved Domains (1) summary
    cl17037
    Location:1443
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. NM_052970.5NP_443202.3  heat shock 70 kDa protein 12B isoform 1

    See identical proteins and their annotated locations for NP_443202.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL109804, BC110881, BC117284
    Consensus CDS
    CCDS13061.1
    UniProtKB/Swiss-Prot
    Q96MM6
    Related
    ENSP00000254963.2, ENST00000254963.7
    Conserved Domains (1) summary
    cl17037
    Location:61529
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3732685..3753111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027635.1XP_016883124.1  heat shock 70 kDa protein 12B isoform X4

  2. XM_017027632.2XP_016883121.1  heat shock 70 kDa protein 12B isoform X1

    UniProtKB/Swiss-Prot
    Q96MM6
    Conserved Domains (1) summary
    cl17037
    Location:61529
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
  3. XM_017027633.1XP_016883122.1  heat shock 70 kDa protein 12B isoform X2

  4. XM_017027634.1XP_016883123.1  heat shock 70 kDa protein 12B isoform X4

  5. XM_011529151.2XP_011527453.1  heat shock 70 kDa protein 12B isoform X3

    See identical proteins and their annotated locations for XP_011527453.1

    UniProtKB/TrEMBL
    B4DLR4
    Conserved Domains (1) summary
    cl17037
    Location:1363
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
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