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IL22RA2 interleukin 22 receptor subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 116379, updated on 12-Aug-2018

Summary

Official Symbol
IL22RA2provided by HGNC
Official Full Name
interleukin 22 receptor subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:14901
See related
Ensembl:ENSG00000164485 MIM:606648; Vega:OTTHUMG00000015655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
Summary
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IL22RA2 in Genome Data Viewer
Location:
6q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (137143820..137173648, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137464957..137494785, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene neuroblastoma highly expressed 1 Neighboring gene interleukin 20 receptor subunit alpha Neighboring gene interferon gamma receptor 1 Neighboring gene uncharacterized LOC105378017

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
    Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150509, MGC150510

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-22 binding IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-22 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-22 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-22 receptor subunit alpha-2
Names
cytokine receptor class-II member 10
cytokine receptor family type 2, soluble 1
interleukin 22 receptor, alpha 2
interleukin 22-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052962.2NP_443194.1  interleukin-22 receptor subunit alpha-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI824338, AJ313162, AY040566
    Consensus CDS
    CCDS5182.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000296980.2, OTTHUMP00000017283, ENST00000296980.6, OTTHUMT00000042399
    Conserved Domains (2) summary
    pfam01108
    Location:24146
    Tissue_fac; Tissue factor
    pfam09294
    Location:158263
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  2. NM_181309.1NP_851826.1  interleukin-22 receptor subunit alpha-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_851826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040566
    Consensus CDS
    CCDS5183.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000296979.4, OTTHUMP00000017282, ENST00000349184.8, OTTHUMT00000042398
    Conserved Domains (2) summary
    pfam01108
    Location:23114
    Tissue_fac; Tissue factor
    pfam09294
    Location:126231
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  3. NM_181310.1NP_851827.1  interleukin-22 receptor subunit alpha-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_851827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region, which leads to a translation frameshift, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040568
    Consensus CDS
    CCDS5184.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000340920.3, OTTHUMP00000017284, ENST00000339602.3, OTTHUMT00000042400
    Conserved Domains (1) summary
    pfam01108
    Location:24114
    Tissue_fac; Tissue factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    137143820..137173648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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