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IL22RA2 interleukin 22 receptor subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 116379, updated on 1-Jun-2020

Summary

Official Symbol
IL22RA2provided by HGNC
Official Full Name
interleukin 22 receptor subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:14901
See related
Ensembl:ENSG00000164485 MIM:606648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
Summary
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IL22RA2 in Genome Data Viewer
Location:
6q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (137143820..137173644, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137464957..137494785, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene neuroblastoma highly expressed 1 Neighboring gene interleukin 20 receptor subunit alpha Neighboring gene interferon gamma receptor 1 Neighboring gene uncharacterized LOC105378017

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150509, MGC150510

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-22 binding IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-22 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-22 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-22 receptor subunit alpha-2
Names
cytokine receptor class-II member 10
cytokine receptor family type 2, soluble 1
interleukin 22 receptor, alpha 2
interleukin 22-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052962.3NP_443194.1  interleukin-22 receptor subunit alpha-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI824338, AJ313162, AY040566
    Consensus CDS
    CCDS5182.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000296980.2, ENST00000296980.7
    Conserved Domains (2) summary
    pfam01108
    Location:24146
    Tissue_fac; Tissue factor
    pfam09294
    Location:158263
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  2. NM_181309.2NP_851826.1  interleukin-22 receptor subunit alpha-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_851826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040566
    Consensus CDS
    CCDS5183.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000296979.4, ENST00000349184.8
    Conserved Domains (2) summary
    pfam01108
    Location:23114
    Tissue_fac; Tissue factor
    pfam09294
    Location:126231
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
  3. NM_181310.2NP_851827.1  interleukin-22 receptor subunit alpha-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_851827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region, which leads to a translation frameshift, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040568
    Consensus CDS
    CCDS5184.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000340920.3, ENST00000339602.3
    Conserved Domains (1) summary
    pfam01108
    Location:24114
    Tissue_fac; Tissue factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    137143820..137173644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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