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CKS1B CDC28 protein kinase regulatory subunit 1B [ Homo sapiens (human) ]

Gene ID: 1163, updated on 9-Feb-2020

Summary

Official Symbol
CKS1Bprovided by HGNC
Official Full Name
CDC28 protein kinase regulatory subunit 1Bprovided by HGNC
Primary source
HGNC:HGNC:19083
See related
Ensembl:ENSG00000173207 MIM:116900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKS1; ckshs1; PNAS-16; PNAS-18
Summary
CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 29.0), fat (RPKM 22.7) and 24 other tissues See more
Orthologs

Genomic context

See CKS1B in Genome Data Viewer
Location:
1q21.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (154974642..154979251)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154947118..154951725)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 2 Neighboring gene uncharacterized LOC101928120 Neighboring gene SHC adaptor protein 1 Neighboring gene microRNA 4258 Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene lens epithelial protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cyclin-dependent kinases regulatory subunit 1
Names
CDC2-associated protein CKS1
CDC28 protein kinase 1B
NB4 apoptosis/differentiation related protein
cell division control protein CKS1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001826.3NP_001817.1  cyclin-dependent kinases regulatory subunit 1

    See identical proteins and their annotated locations for NP_001817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding variant.
    Source sequence(s)
    AL451085, BQ883992, CN347951
    Consensus CDS
    CCDS1077.1
    UniProtKB/Swiss-Prot
    P61024
    UniProtKB/TrEMBL
    Q5T178
    Related
    ENSP00000311083.5, ENST00000308987.6
    Conserved Domains (1) summary
    pfam01111
    Location:873
    CKS; Cyclin-dependent kinase regulatory subunit

RNA

  1. NR_024163.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site at the 3' end of the first exon compared to variant 1. There is no evidence that this variant encodes a protein.
    Source sequence(s)
    BQ883992, CB161621, CN347951
    Related
    ENST00000368439.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    154974642..154979251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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