Format

Send to:

Choose Destination

CMTM5 CKLF like MARVEL transmembrane domain containing 5 [ Homo sapiens (human) ]

Gene ID: 116173, updated on 23-Nov-2021

Summary

Official Symbol
CMTM5provided by HGNC
Official Full Name
CKLF like MARVEL transmembrane domain containing 5provided by HGNC
Primary source
HGNC:HGNC:19176
See related
Ensembl:ENSG00000166091 MIM:607888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKLFSF5
Summary
This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in brain (RPKM 15.6), bone marrow (RPKM 1.3) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CMTM5 in Genome Data Viewer
Location:
14q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (23376432..23379772)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23846255..23848981)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene embryonal Fyn-associated substrate Neighboring gene interleukin 25 Neighboring gene myosin heavy chain 6 Neighboring gene microRNA 208a Neighboring gene VISTA enhancer hs2155

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37521

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 5
Names
chemokine-like factor super family 5
chemokine-like factor superfamily member 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037288.2NP_001032365.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform c

    See identical proteins and their annotated locations for NP_001032365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AF479262, AY820135, BC013109
    Consensus CDS
    CCDS32050.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000372259.2, ENST00000382809.2
    Conserved Domains (1) summary
    cl04571
    Location:29105
    MARVEL; Membrane-associating domain
  2. NM_001288744.2NP_001275673.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform d

    See identical proteins and their annotated locations for NP_001275673.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.
    Source sequence(s)
    AF527949
    Consensus CDS
    CCDS73618.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000380404.3, ENST00000397227.7
  3. NM_001288745.2NP_001275674.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform e

    See identical proteins and their annotated locations for NP_001275674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AF527948
    Consensus CDS
    CCDS73619.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000344160.4, ENST00000342473.8
  4. NM_001288746.2NP_001275675.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform f

    See identical proteins and their annotated locations for NP_001275675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) includes an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (f) is longer, compared to isoform a.
    Source sequence(s)
    AF527413
    Consensus CDS
    CCDS73617.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000344819.4, ENST00000339180.9
    Conserved Domains (1) summary
    pfam01284
    Location:29152
    MARVEL; Membrane-associating domain
  5. NM_138460.3NP_612469.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform a

    See identical proteins and their annotated locations for NP_612469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AL049829
    Consensus CDS
    CCDS9598.1
    UniProtKB/Swiss-Prot
    Q96DZ9
    Related
    ENSP00000352270.3, ENST00000359320.7
    Conserved Domains (1) summary
    pfam01284
    Location:29139
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    23376432..23379772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449466.1XP_024305234.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    Conserved Domains (1) summary
    pfam01284
    Location:29113
    MARVEL; Membrane-associating domain
  2. XM_024449467.1XP_024305235.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    Conserved Domains (1) summary
    pfam01284
    Location:29113
    MARVEL; Membrane-associating domain
  3. XM_024449465.1XP_024305233.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    Conserved Domains (1) summary
    pfam01284
    Location:29113
    MARVEL; Membrane-associating domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181618.1: Suppressed sequence

    Description
    NM_181618.1: This RefSeq was permanently suppressed because it represents a likely non-sense mediated decay (NMD) candidate, there is insufficient support for the transcript and the protein is not supported by current protein hom
Support Center