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Biochem Biophys Res Commun. 2014 May 2;447(2):304-10. doi: 10.1016/j.bbrc.2014.03.158. Epub 2014 Apr 8.

CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma.

Author information

1
Central Laboratory, Peking University School of Stomatology, Beijing, China.
2
Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing, China.
3
Department of Oral Pathology, Peking University School of Stomatology, Beijing, China.
4
Department of Oral Pathology, Peking University School of Stomatology, Beijing, China. Electronic address: litiejun22@vip.sina.com.

Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancies in the head and neck region. CKLF-like MARVEL transmembrane domain-containing member 5 (CMTM5) has been recently implicated as a tumor suppressor gene in several cancer types. Herein, we examined the expression and function of CMTM5 in oral squamous cell carcinoma. CMTM5 was down-regulated in oral squamous cell lines and tumor samples from patients with promoter methylation. Treatment with the demethylating agent 5-aza-2'-deoxycytidine restored CMTM5 expression. In the OSCC cell lines CAL27 and GNM, the ectopic expression of CMTM5-v1 strongly inhibited cell proliferation and migration and induced apoptosis. In addition, CMTM5-v1 inhibited tumor formation in vivo. Therefore, CMTM5 might act as a putative tumor suppressor gene through promoter methylation in oral squamous cell carcinoma.

KEYWORDS:

CMTM5; Oral squamous cell carcinoma; Promoter methylation; Tumor suppressor

PMID:
24721428
DOI:
10.1016/j.bbrc.2014.03.158
[Indexed for MEDLINE]
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