Parp2 poly (ADP-ribose) polymerase family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp2provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 2provided by MGI
Primary source: MGI:MGI:1341112
See related: Ensembl:ENSMUSG00000036023 AllianceGenome:MGI:1341112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD2; Adprt2; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2
Summary: Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.7), liver E14 (RPKM 15.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 26.25 cM; 14 C1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51045347..51058758)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (50807897..50821301)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
Title: Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.
miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process.
Title: miRNA-149 targets PARP-2 in endometrial epithelial and stromal cells to regulate the trophoblast attachment process.
Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.
Title: Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.
Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
Title: Dual function of HPF1 in the modulation of PARP1 and PARP2 activities.
Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8.
Title: Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8.
Hsa-circ-0068566 inhibited the development of myocardial ischemia reperfusion injury by regulating hsa-miR-6322/PARP2 signal pathway.
Title: Hsa-circ-0068566 inhibited the development of myocardial ischemia reperfusion injury by regulating hsa-miR-6322/PARP2 signal pathway.
Silencing of PARP2 Blocks Autophagic Degradation.
Title: Silencing of PARP2 Blocks Autophagic Degradation.
Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.
Title: Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.
Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.
Title: Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.
myeloid deletion of PARP2, but not PARP1, increases the population of immature myeloid cells in bone marrow, and impairs the expression of chemokines such as CCL3 through enhancing the transcriptional repression by beta-catenin.
Title: Differential regulation of breast cancer bone metastasis by PARP1 and PARP2.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126406 (e-PCR)
- UniSTS:163114

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

UniSTS:492996 (e-PCR)
- UniSTS:492996

Homology

Homologs of the Parp2 gene: The Parp2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 392 organisms have orthologs with human gene Parp2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables NAD DNA ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+ ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+- protein-aspartate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-glutamate ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-serine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables poly-ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
enables poly-ADP-D-ribose modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	TAS Traceable Author Statement more info	PubMed
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within base-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in decidualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: poly [ADP-ribose] polymerase 2

Names: ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2; ADP-ribosyltransferase diphtheria toxin-like 2; DNA ADP-ribosyltransferase PARP2; NAD(+) ADP-ribosyltransferase 2; poly[ADP-ribose] synthase 2; poly[ADP-ribose] synthetase 2; protein poly-ADP-ribosyltransferase PARP2

NP_033762.1

EC 2.4.2.30

XP_006518505.1

EC 2.4.2.30

XP_036014293.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009632.3 → NP_033762.1 poly [ADP-ribose] polymerase 2

See identical proteins and their annotated locations for NP_033762.1

Status: VALIDATED

Source sequence(s)

AC027184

Consensus CDS

CCDS27025.1

UniProtKB/Swiss-Prot

O88554, Q99N29

Related

ENSMUSP00000048877.6, ENSMUST00000036126.7

Conserved Domains (3) summary

cd08003
Location:86 → 188

WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases

cd01437
Location:207 → 552

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:341 → 553

PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

51045347..51058758

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158400.1 → XP_036014293.1 poly [ADP-ribose] polymerase 2 isoform X2

Conserved Domains (1) summary

cd01437
Location:21 → 281

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
XM_006518442.4 → XP_006518505.1 poly [ADP-ribose] polymerase 2 isoform X1

See identical proteins and their annotated locations for XP_006518505.1

UniProtKB/Swiss-Prot

O88554

Conserved Domains (1) summary

PLN03124
Location:14 → 518

PLN03124; poly [ADP-ribose] polymerase; Provisional