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Parp2 poly (ADP-ribose) polymerase family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 11546, updated on 1-Mar-2024

Summary

Official Symbol
Parp2provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 2provided by MGI
Primary source
MGI:MGI:1341112
See related
Ensembl:ENSMUSG00000036023 AllianceGenome:MGI:1341112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD2; Adprt2; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2
Summary
Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within base-excision repair and extrinsic apoptotic signaling pathway. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; gonad; liver; retina; and thymus. Orthologous to human PARP2 (poly(ADP-ribose) polymerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.7), liver E14 (RPKM 15.1) and 25 other tissues See more
Orthologs
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Genomic context

See Parp2 in Genome Data Viewer
Location:
14 26.25 cM; 14 C1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51045347..51058758)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50807897..50821301)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cyclin B1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E753 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1 Neighboring gene predicted gene, 52116 Neighboring gene STARR-positive B cell enhancer ABC_E8557 Neighboring gene predicted gene, 26782

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD DNA ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+- protein-aspartate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein-serine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables poly-ADP-D-ribose binding ISO
Inferred from Sequence Orthology
more info
 
enables poly-ADP-D-ribose modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hippocampal neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxygen-glucose deprivation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
poly [ADP-ribose] polymerase 2
Names
ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2
ADP-ribosyltransferase diphtheria toxin-like 2
DNA ADP-ribosyltransferase PARP2
NAD(+) ADP-ribosyltransferase 2
poly[ADP-ribose] synthase 2
poly[ADP-ribose] synthetase 2
protein poly-ADP-ribosyltransferase PARP2
NP_001409012.1
NP_001409013.1
NP_001409014.1
NP_033762.1
XP_036014293.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001422083.1NP_001409012.1  poly [ADP-ribose] polymerase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027184
  2. NM_001422084.1NP_001409013.1  poly [ADP-ribose] polymerase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC027184
  3. NM_001422085.1NP_001409014.1  poly [ADP-ribose] polymerase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC027184
  4. NM_009632.4NP_033762.1  poly [ADP-ribose] polymerase 2 isoform 1

    See identical proteins and their annotated locations for NP_033762.1

    Status: VALIDATED

    Source sequence(s)
    AC027184
    Consensus CDS
    CCDS27025.1
    UniProtKB/Swiss-Prot
    O88554, Q99N29
    Related
    ENSMUSP00000048877.6, ENSMUST00000036126.7
    Conserved Domains (3) summary
    cd08003
    Location:86188
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:207552
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00644
    Location:341553
    PARP; Poly(ADP-ribose) polymerase catalytic domain

RNA

  1. NR_185484.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC027184
  2. NR_185485.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC027184

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51045347..51058758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158400.1XP_036014293.1  poly [ADP-ribose] polymerase 2 isoform X2

    Conserved Domains (1) summary
    cd01437
    Location:21281
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...