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Parp2 poly (ADP-ribose) polymerase family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 11546, updated on 11-Jun-2019

Summary

Official Symbol
Parp2provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 2provided by MGI
Primary source
MGI:MGI:1341112
See related
Ensembl:ENSMUSG00000036023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD2; Adprt2; C78626; PARP-2; ADPRT-2; Adprtl2; mPARP-2; Aspartl2; pADPRT-2
Expression
Ubiquitous expression in CNS E11.5 (RPKM 20.7), liver E14 (RPKM 15.1) and 25 other tissues See more
Orthologs

Genomic context

See Parp2 in Genome Data Viewer
Location:
14 26.25 cM; 14 C1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (50807897..50821301)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (51427621..51440975)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cyclin B1 interacting protein 1 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1 Neighboring gene predicted gene, 26782 Neighboring gene kelch-like 33

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • BER complex, organism-specific biosystem (from KEGG)
    BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
  • BER complex, conserved biosystem (from KEGG)
    BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
  • Base excision repair, organism-specific biosystem (from KEGG)
    Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Base excision repair, conserved biosystem (from KEGG)
    Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein ADP-ribosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring glycosyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
DNA repair TAS
Traceable Author Statement
more info
PubMed 
base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
poly [ADP-ribose] polymerase 2
Names
ADP-ribosyltransferase (NAD+, poly(ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) 2
ADP-ribosyltransferase diphtheria toxin-like 2
DNA ADP-ribosyltransferase PARP2
NAD(+) ADP-ribosyltransferase 2
poly[ADP-ribose] synthase 2
poly[ADP-ribose] synthetase 2
protein poly-ADP-ribosyltransferase PARP2
NP_033762.1
XP_006518505.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009632.3NP_033762.1  poly [ADP-ribose] polymerase 2

    See identical proteins and their annotated locations for NP_033762.1

    Status: VALIDATED

    Source sequence(s)
    AC027184
    Consensus CDS
    CCDS27025.1
    UniProtKB/Swiss-Prot
    O88554
    Related
    ENSMUSP00000048877.5, ENSMUST00000036126.6
    Conserved Domains (3) summary
    cd08003
    Location:86188
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:207552
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00644
    Location:341553
    PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    50807897..50821301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518442.3XP_006518505.1  poly [ADP-ribose] polymerase 2 isoform X1

    See identical proteins and their annotated locations for XP_006518505.1

    UniProtKB/Swiss-Prot
    O88554
    Conserved Domains (3) summary
    cd08003
    Location:49151
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:170515
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00644
    Location:304516
    PARP; Poly(ADP-ribose) polymerase catalytic domain
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