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PARP2 poly(ADP-ribose) polymerase 2 [ Homo sapiens (human) ]

Gene ID: 10038, updated on 21-Dec-2019

Summary

Official Symbol
PARP2provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase 2provided by HGNC
Primary source
HGNC:HGNC:272
See related
Ensembl:ENSG00000129484 MIM:607725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2
Summary
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See PARP2 in Genome Data Viewer
Location:
14q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20343041..20357904)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20811773..20826063)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cyclin B1 interacting protein 1 Neighboring gene small nucleolar RNA, H/ACA box 79B Neighboring gene small nucleolar RNA, C/D box 126 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 382

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair TAS
Traceable Author Statement
more info
PubMed 
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
poly [ADP-ribose] polymerase 2
Names
ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase diphtheria toxin-like 2
ADPRT-2
DNA ADP-ribosyltransferase PARP2
NAD(+) ADP-ribosyltransferase 2
hPARP-2
poly (ADP-ribose) polymerase family, member 2
poly (ADP-ribosyl) transferase-like 2
poly[ADP-ribose] synthase 2
poly[ADP-ribose] synthetase 2
protein poly-ADP-ribosyltransferase PARP2
NP_001036083.1
NP_005475.2
XP_005267304.1
XP_016876401.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033959.1 RefSeqGene

    Range
    5001..19291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042618.1NP_001036083.1  poly [ADP-ribose] polymerase 2 isoform 2

    See identical proteins and their annotated locations for NP_001036083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' coding region, as compared to variant 1. The reading frame is not changed but the transcript encodes 13 aa less than variant 1.
    Source sequence(s)
    AJ236912, BU541261, DA354586
    Consensus CDS
    CCDS45077.1
    UniProtKB/Swiss-Prot
    Q9UGN5
    Related
    ENSP00000392972.3, ENST00000429687.7
    Conserved Domains (1) summary
    cl27333
    Location:52566
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain
  2. NM_005484.3NP_005475.2  poly [ADP-ribose] polymerase 2 isoform 1

    See identical proteins and their annotated locations for NP_005475.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a longer isoform (1).
    Source sequence(s)
    AJ236912, AK001980, BU541261, DA354586
    Consensus CDS
    CCDS41910.1
    UniProtKB/Swiss-Prot
    Q9UGN5
    Related
    ENSP00000250416.5, ENST00000250416.9
    Conserved Domains (3) summary
    cd08003
    Location:106208
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:231576
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00644
    Location:365577
    PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20343041..20357904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020912.1XP_016876401.1  poly [ADP-ribose] polymerase 2 isoform X2

    Conserved Domains (2) summary
    cd08003
    Location:93195
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:218476
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
  2. XM_005267247.3XP_005267304.1  poly [ADP-ribose] polymerase 2 isoform X1

    Conserved Domains (2) summary
    cd08003
    Location:106208
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:231489
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
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