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PARP2 poly(ADP-ribose) polymerase 2 [ Homo sapiens (human) ]

Gene ID: 10038, updated on 12-Aug-2018

Summary

Official Symbol
PARP2provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase 2provided by HGNC
Primary source
HGNC:HGNC:272
See related
Ensembl:ENSG00000129484 MIM:607725; Vega:OTTHUMG00000166106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD2; ADPRT2; PARP-2; ADPRTL2; ADPRTL3; pADPRT-2
Summary
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 14.3), testis (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See PARP2 in Genome Data Viewer
Location:
14q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (20343041..20357904)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20811773..20826063)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene cyclin B1 interacting protein 1 Neighboring gene small nucleolar RNA, H/ACA box 79B Neighboring gene small nucleolar RNA, C/D box 126 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 382

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • BER complex, organism-specific biosystem (from KEGG)
    BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
  • BER complex, conserved biosystem (from KEGG)
    BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
  • Base Excision Repair, organism-specific biosystem (from REACTOME)
    Base Excision Repair, organism-specific biosystemOf the three major pathways involved in the repair of nucleotide damage in DNA, base excision repair (BER) involves the greatest number of individual enzymatic activities. This is the consequence of ...
  • Base excision repair, organism-specific biosystem (from KEGG)
    Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • Base excision repair, conserved biosystem (from KEGG)
    Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
  • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
    DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
  • DNA Double-Strand Break Repair, organism-specific biosystem (from REACTOME)
    DNA Double-Strand Break Repair, organism-specific biosystemNumerous types of DNA damage can occur within a cell due to the endogenous production of oxygen free radicals, normal alkylation reactions, or exposure to exogenous radiations and chemicals. Double-s...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Dual Incision in GG-NER, organism-specific biosystem (from REACTOME)
    Dual Incision in GG-NER, organism-specific biosystemDouble incision at the damaged DNA strand excises the oligonucleotide that contains the lesion from the open bubble. The excised oligonucleotide is ~27-30 bases long. Incision 5' to the damage site, ...
  • Formation of Incision Complex in GG-NER, organism-specific biosystem (from REACTOME)
    Formation of Incision Complex in GG-NER, organism-specific biosystemAfter the XPC complex and the UV-DDB complex bind damaged DNA, a basal transcription factor TFIIH is recruited to the nucleotide excision repair (NER) site (Volker et al. 2001, Riedl et al. 2003). DN...
  • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
    Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
  • HDR through MMEJ (alt-NHEJ), organism-specific biosystem (from REACTOME)
    HDR through MMEJ (alt-NHEJ), organism-specific biosystemHomology directed repair (HDR) through microhomology-mediated end joining (MMEJ) is an error prone process also known as alternative nonhomologous end joining (alt-NHEJ), although it does not involve...
  • Homology Directed Repair, organism-specific biosystem (from REACTOME)
    Homology Directed Repair, organism-specific biosystemHomology directed repair (HDR) of DNA double strand breaks (DSBs) requires resection of DNA DSB ends. Resection creates 3'-ssDNA overhangs which then anneal with a homologous DNA sequence. This homol...
  • NAD+ biosynthetic pathways, organism-specific biosystem (from WikiPathways)
    NAD+ biosynthetic pathways, organism-specific biosystemNAD+ biosynthetic pathways. NAD+ levels are maintained by three independent pathways. First, the Preiss-Handler pathway uses dietary nicotinic acid and the enzyme nicotinic acid phosphoribosyltransfe...
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • POLB-Dependent Long Patch Base Excision Repair, organism-specific biosystem (from REACTOME)
    POLB-Dependent Long Patch Base Excision Repair, organism-specific biosystemDuring POLB-dependent long patch base excision repair (BER), PARP1 and/or PARP2 is recruited to the BER site along with flap endonuclease FEN1. PARP1 and/or PARP2 and FEN1 facilitate POLB-mediated st...
  • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Telomerase, organism-specific biosystem
    Regulation of Telomerase
  • Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystem (from REACTOME)
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystemWhile the single nucleotide replacement pathway appears to facilitate the repair of most damaged bases, an alternative BER pathway is evoked when the structure of the 5'-terminal sugar phosphate is s...
  • Resolution of Abasic Sites (AP sites), organism-specific biosystem (from REACTOME)
    Resolution of Abasic Sites (AP sites), organism-specific biosystemResolution of AP sites can occur through the single nucleotide replacement pathway or through the multiple nucleotide patch replacement pathway, also known as the long-patch base excision repair (BER...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair TAS
Traceable Author Statement
more info
PubMed 
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
poly [ADP-ribose] polymerase 2
Names
ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2
ADP-ribosyltransferase diphtheria toxin-like 2
ADPRT-2
NAD(+) ADP-ribosyltransferase 2
hPARP-2
poly (ADP-ribose) polymerase family, member 2
poly (ADP-ribosyl) transferase-like 2
poly[ADP-ribose] synthase 2
poly[ADP-ribose] synthetase 2
NP_001036083.1
NP_005475.2
XP_005267304.1
XP_016876401.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033959.1 RefSeqGene

    Range
    5001..19291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042618.1NP_001036083.1  poly [ADP-ribose] polymerase 2 isoform 2

    See identical proteins and their annotated locations for NP_001036083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' coding region, as compared to variant 1. The reading frame is not changed but the transcript encodes 13 aa less than variant 1.
    Source sequence(s)
    AJ236912, BU541261, DA354586
    Consensus CDS
    CCDS45077.1
    UniProtKB/Swiss-Prot
    Q9UGN5
    Related
    ENSP00000392972.3, OTTHUMP00000231900, ENST00000429687.7, OTTHUMT00000387845
    Conserved Domains (1) summary
    cl27333
    Location:52566
    PARP_reg; Poly(ADP-ribose) polymerase, regulatory domain
  2. NM_005484.3NP_005475.2  poly [ADP-ribose] polymerase 2 isoform 1

    See identical proteins and their annotated locations for NP_005475.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a longer isoform (1).
    Source sequence(s)
    AJ236912, AK001980, BU541261, DA354586
    Consensus CDS
    CCDS41910.1
    UniProtKB/Swiss-Prot
    Q9UGN5
    Related
    ENSP00000250416.5, OTTHUMP00000231902, ENST00000250416.9, OTTHUMT00000387847
    Conserved Domains (3) summary
    cd08003
    Location:106208
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:231576
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00644
    Location:365577
    PARP; Poly(ADP-ribose) polymerase catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    20343041..20357904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020912.1XP_016876401.1  poly [ADP-ribose] polymerase 2 isoform X2

    Conserved Domains (2) summary
    cd08003
    Location:93195
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:218476
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
  2. XM_005267247.3XP_005267304.1  poly [ADP-ribose] polymerase 2 isoform X1

    Conserved Domains (2) summary
    cd08003
    Location:106208
    WGR_PARP2_like; WGR domain of poly(ADP-ribose) polymerases
    cd01437
    Location:231489
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
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