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Parp1 poly (ADP-ribose) polymerase family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 11545, updated on 13-Feb-2024

Summary

Official Symbol
Parp1provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 1provided by MGI
Primary source
MGI:MGI:1340806
See related
Ensembl:ENSMUSG00000026496 AllianceGenome:MGI:1340806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PARP; PPOL; ARTD1; Adprp; Adprt1; msPARP; parp-1; sPARP-1; 5830444G22Rik
Summary
Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 60.8), CNS E14 (RPKM 38.0) and 25 other tissues See more
Orthologs
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Genomic context

See Parp1 in Genome Data Viewer
Location:
1 H4; 1 84.44 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180396456..180428564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180568891..180600999)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mechanosensory transduction mediator Neighboring gene STARR-positive B cell enhancer ABC_E5872 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182471419-182471720 Neighboring gene STARR-positive B cell enhancer ABC_E3342 Neighboring gene predicted gene, 31986 Neighboring gene STARR-seq mESC enhancer starr_03207 Neighboring gene microRNA 6904 Neighboring gene STARR-seq mESC enhancer starr_03209 Neighboring gene predicted gene, 53485 Neighboring gene lin-9 DREAM MuvB core complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD DNA ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables NAD+- protein-aspartate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+- protein-aspartate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+-histone H2BS6 serine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-histone H3S10 serine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+-protein-glutamate ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein-histidine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein-serine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein-tyrosine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription regulator activator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within base-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbohydrate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to superoxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within double-strand break repair IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitochondrial DNA metabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within mitochondrial DNA repair ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of adipose tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription, elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myofibroblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of single strand break repair IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of single strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein modification process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of base-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian sleep/wake cycle, non-REM sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of growth rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of single strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in replication fork reversal ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in voluntary musculoskeletal movement IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
poly [ADP-ribose] polymerase 1
Names
ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
ADP-ribosyltransferase diphtheria toxin-like 1
ADPRT 1
DNA ADP-ribosyltransferase PARP1
NAD(+) ADP-ribosyltransferase 1
poly(ADP-ribose) polymerase
poly[ADP-ribose] synthase 1
poly[ADP-ribose] synthetase 1
protein poly-ADP-ribosyltransferase PARP1
NP_031441.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007415.3NP_031441.2  poly [ADP-ribose] polymerase 1

    See identical proteins and their annotated locations for NP_031441.2

    Status: VALIDATED

    Source sequence(s)
    AC167020, AK159433, CJ153239
    Consensus CDS
    CCDS15569.1
    UniProtKB/TrEMBL
    Q3TIV3, Q3TM68, Q921K2
    Related
    ENSMUSP00000027777.7, ENSMUST00000027777.12
    Conserved Domains (6) summary
    cd08001
    Location:543645
    WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
    PLN03123
    Location:91010
    PLN03123; poly [ADP-ribose] polymerase; Provisional
    cd01437
    Location:6621006
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00533
    Location:389462
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam00645
    Location:1287
    zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
    pfam08063
    Location:281332
    PADR1; PADR1 (NUC008) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    180396456..180428564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)