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top3a DNA topoisomerase III alpha [ Takifugu rubripes (torafugu) ]

Gene ID: 115246427, updated on 17-Mar-2024

Summary

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Gene symbol
top3a
Gene description
DNA topoisomerase III alpha
See related
Ensembl:ENSTRUG00000006332
Gene type
protein coding
RefSeq status
MODEL
Organism
Takifugu rubripes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu
Orthologs
human zebrafish all
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Genomic context

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See top3a in Genome Data Viewer
Location:
chromosome: 5
Exon count:
20
Annotation release Status Assembly Chr Location
103 current fTakRub1.2 (GCF_901000725.2) 5 NC_042289.1 (4291608..4301363, complement)

Chromosome 5 - NC_042289.1Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase p300 Neighboring gene uncharacterized LOC101079131 Neighboring gene Smith-Magenis syndrome chromosome region, candidate 8a Neighboring gene BUD31 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_042289.1 Chromosome 5 Reference fTakRub1.2 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA topological change IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA topoisomerase 3-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Takifugu rubripes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fTakRub1.2 Primary Assembly

Genomic

  1. NC_042289.1 Reference fTakRub1.2 Primary Assembly

    Range
    4291608..4301363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029836203.1 → XP_029692063.1  DNA topoisomerase 3-alpha isoform X2

    UniProtKB/TrEMBL
    A0A674P7U1
    Related
    ENSTRUP00000081788.1, ENSTRUT00000068461.1
    Conserved Domains (5) summary
    cd03362
    Location:10 → 168
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    cd00186
    Location:177 → 593
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam06839
    Location:795 → 834
    zf-GRF; GRF zinc finger
    pfam01396
    Location:631 → 670
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
    pfam16588
    Location:950 → 967
    zf-C2H2_10; C2H2 zinc-finger

  2. XM_029836202.1 → XP_029692062.1  DNA topoisomerase 3-alpha isoform X1

    UniProtKB/TrEMBL
    A0A674MEJ0, A0A674MS71
    Related
    ENSTRUP00000063973.1, ENSTRUT00000065169.1
    Conserved Domains (4) summary
    cd03362
    Location:51 → 209
    TOPRIM_TopoIA_TopoIII; The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA ...
    cd00186
    Location:218 → 634
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam06839
    Location:836 → 875
    zf-GRF; GRF zinc finger
    pfam01396
    Location:672 → 711
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
Nucleotide Protein
Heading Accession and Version

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