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TOP3A DNA topoisomerase III alpha [ Homo sapiens (human) ]

Gene ID: 7156, updated on 1-Jun-2020

Summary

Official Symbol
TOP3Aprovided by HGNC
Official Full Name
DNA topoisomerase III alphaprovided by HGNC
Primary source
HGNC:HGNC:11992
See related
Ensembl:ENSG00000177302 MIM:601243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOP3; PEOB5; ZGRF7; MGRISCE2
Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in testis (RPKM 4.1), bone marrow (RPKM 3.1) and 25 other tissues See more
Orthologs

Genomic context

See TOP3A in Genome Data Viewer
Location:
17p11.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (18269958..18314996, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18177235..18218321, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene LLGL scribble cell polarity complex component 1 Neighboring gene FLII actin remodeling protein Neighboring gene mitochondrial elongation factor 2 Neighboring gene ribosomal protein L21 pseudogene 121 Neighboring gene ribosomal protein L7a pseudogene 65 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene serine hydroxymethyltransferase 1 Neighboring gene microRNA 6778

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA topoisomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IDA
Inferred from Direct Assay
more info
PubMed 
chromosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitochondrial DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA topoisomerase 3-alpha
Names
topo III-alpha
topoisomerase (DNA) III alpha
zinc finger, GRF-type containing 7
NP_001307688.1
NP_004609.1
XP_011522303.1
XP_024306671.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320759.2NP_001307688.1  DNA topoisomerase 3-alpha isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in a novel 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC127537, AF086042, AK296437, AW294300, BM462184, BY996313
    UniProtKB/Swiss-Prot
    Q13472
    Conserved Domains (6) summary
    COG0551
    Location:557633
    YrdD; ssDNA-binding Zn-finger and Zn-ribbon domains of topoisomerase 1 [Replication, recombination and repair]
    cd00186
    Location:107522
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam01131
    Location:100507
    Topoisom_bac; DNA topoisomerase
    pfam01396
    Location:560599
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
    pfam06839
    Location:800844
    zf-GRF; GRF zinc finger
    cl00718
    Location:1898
    TOPRIM; Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from ...
  2. NM_004618.5NP_004609.1  DNA topoisomerase 3-alpha isoform 1

    See identical proteins and their annotated locations for NP_004609.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127537, AF086042, AW294300, BC051748, BM462184
    Consensus CDS
    CCDS11194.1
    UniProtKB/Swiss-Prot
    Q13472
    Related
    ENSP00000321636.5, ENST00000321105.10
    Conserved Domains (6) summary
    cd03362
    Location:35193
    TOPRIM_TopoIA_TopoIII; TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving ...
    COG0550
    Location:35634
    TopA; DNA topoisomerase IA [Replication, recombination and repair]
    COG0551
    Location:652728
    YrdD; ssDNA-binding Zn-finger and Zn-ribbon domains of topoisomerase 1 [Replication, recombination and repair]
    cd00186
    Location:202617
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam01396
    Location:655694
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
    pfam06839
    Location:895939
    zf-GRF; GRF zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    18269958..18314996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450903.1XP_024306671.1  DNA topoisomerase 3-alpha isoform X1

    Conserved Domains (3) summary
    cd00186
    Location:1310
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam06839
    Location:588632
    zf-GRF; GRF zinc finger
    pfam01396
    Location:348387
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
  2. XM_011524001.2XP_011522303.1  DNA topoisomerase 3-alpha isoform X2

    See identical proteins and their annotated locations for XP_011522303.1

    UniProtKB/TrEMBL
    B4DSJ0
    Conserved Domains (3) summary
    cl21690
    Location:1147
    TOP1Ac; DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA ...
    pfam01396
    Location:185224
    zf-C4_Topoisom; Topoisomerase DNA binding C4 zinc finger
    pfam06839
    Location:425469
    zf-GRF; GRF zinc finger

RNA

  1. XR_001752601.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017363819.1 Reference GRCh38.p13 PATCHES

    Range
    31802..75368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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