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CKB creatine kinase B [ Homo sapiens (human) ]

Gene ID: 1152, updated on 5-Sep-2021

Summary

Official Symbol
CKBprovided by HGNC
Official Full Name
creatine kinase Bprovided by HGNC
Primary source
HGNC:HGNC:1991
See related
Ensembl:ENSG00000166165 MIM:123280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29
Summary
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 268.3), prostate (RPKM 227.9) and 18 other tissues See more
Orthologs
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Genomic context

See CKB in Genome Data Viewer
Location:
14q32.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (103519667..103522833, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103986004..103989167, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene ribosomal protein L10a pseudogene 1 Neighboring gene uncharacterized LOC112268130 Neighboring gene tRNA methyltransferase 61A Neighboring gene RNA, U7 small nuclear 160 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables creatine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular chloride ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
creatine kinase B-type
Names
brain creatine kinase
creatine kinase B chain
creatine kinase brain
creatine kinase brain-type
creatine phosphokinase B-type
epididymis luminal protein 211
epididymis secretory protein Li 29
NP_001349460.1
NP_001814.2
XP_016876441.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362531.2NP_001349460.1  creatine kinase B-type isoform 2

    Status: REVIEWED

    Source sequence(s)
    BM684665, BP213119, KU177978
    Conserved Domains (1) summary
    cd00716
    Location:16397
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes
  2. NM_001823.5NP_001814.2  creatine kinase B-type isoform 1

    See identical proteins and their annotated locations for NP_001814.2

    Status: REVIEWED

    Source sequence(s)
    AK312282, BM684665, BP213119
    Consensus CDS
    CCDS9981.1
    UniProtKB/Swiss-Prot
    P12277
    UniProtKB/TrEMBL
    V9HWH2
    Related
    ENSP00000299198.2, ENST00000348956.7
    Conserved Domains (1) summary
    cd00716
    Location:16373
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    103519667..103522833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020952.1XP_016876441.1  creatine kinase B-type isoform X2

    UniProtKB/TrEMBL
    G3V4N7
    Related
    ENSP00000451904.1, ENST00000553878.5
    Conserved Domains (1) summary
    cl02823
    Location:16217
    phosphagen_kinases; Phosphagen (guanidino) kinases
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