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C1QTNF4 C1q and TNF related 4 [ Homo sapiens (human) ]

Gene ID: 114900, updated on 18-Oct-2022

Summary

Official Symbol
C1QTNF4provided by HGNC
Official Full Name
C1q and TNF related 4provided by HGNC
Primary source
HGNC:HGNC:14346
See related
Ensembl:ENSG00000172247 MIM:614911; AllianceGenome:HGNC:14346
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRP4; ZACRP4
Summary
Predicted to enable cytokine activity. Involved in positive regulation of cytokine production and positive regulation of signal transduction. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 5.9), bone marrow (RPKM 0.3) and 2 other tissues See more
Orthologs
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Genomic context

See C1QTNF4 in Genome Data Viewer
Location:
11p11.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (47589667..47595304, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (47750063..47754807, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (47611219..47615963, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene family with sequence similarity 180 member B Neighboring gene mitochondrial carrier 2 Neighboring gene AGBL carboxypeptidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
complement C1q tumor necrosis factor-related protein 4
Names
C1q and tumor necrosis factor related protein 4
C1q/TNF-related protein 4
complement-c1q tumor necrosis factor-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031909.3NP_114115.2  complement C1q tumor necrosis factor-related protein 4 precursor

    See identical proteins and their annotated locations for NP_114115.2

    Status: VALIDATED

    Source sequence(s)
    AC104942
    Consensus CDS
    CCDS7942.1
    UniProtKB/Swiss-Prot
    Q8IV25, Q9BXJ3
    UniProtKB/TrEMBL
    A0A3B0J0L9
    Related
    ENSP00000302274.3, ENST00000302514.4
    Conserved Domains (1) summary
    pfam00386
    Location:178311
    C1q; C1q domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    47589667..47595304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017166.2XP_016872655.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8IV25, Q9BXJ3
    UniProtKB/TrEMBL
    A0A3B0J0L9
    Conserved Domains (1) summary
    pfam00386
    Location:178311
    C1q; C1q domain

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_019805496.1 Reference GRCh38.p14 PATCHES

    Range
    17493..22237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    47750063..47754807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)