U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cygb cytoglobin [ Mus musculus (house mouse) ]

Gene ID: 114886, updated on 27-Feb-2024

Summary

Official Symbol
Cygbprovided by MGI
Official Full Name
cytoglobinprovided by MGI
Primary source
MGI:MGI:2149481
See related
Ensembl:ENSMUSG00000020810 AllianceGenome:MGI:2149481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HGb; Staap; 3110001K20Rik
Summary
Predicted to enable catalase activity; fatty acid peroxidase activity; and heme binding activity. Predicted to be involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of fibroblast migration; and negative regulation of hepatic stellate cell activation. Predicted to act upstream of or within oxygen transport. Located in neuron projection and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; head mesenchyme; and sensory organ. Orthologous to human CYGB (cytoglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 60.4), ovary adult (RPKM 54.6) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cygb in Genome Data Viewer
Location:
11 E2; 11 81.45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116536421..116544887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116645595..116654504, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2O Neighboring gene STARR-seq mESC enhancer starr_31212 Neighboring gene arylalkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2 Neighboring gene STARR-seq mESC enhancer starr_31215 Neighboring gene STARR-seq mESC enhancer starr_31216 Neighboring gene photoreceptor disc component Neighboring gene STARR-positive B cell enhancer ABC_E471 Neighboring gene small nucleolar RNA, C/D box 1C Neighboring gene small nucleolar RNA, C/D box 1B Neighboring gene small nucleolar RNA host gene 16

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbon monoxide binding ISO
Inferred from Sequence Orthology
more info
 
enables catalase activity ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitrite reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxidoreductase activity, acting on a heme group of donors ISO
Inferred from Sequence Orthology
more info
 
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
 
enables oxygen carrier activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatic stellate cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oxygen transport IEA
Inferred from Electronic Annotation
more info
 
involved_in oxygen transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytoglobin
Names
histoglobin
stellate cell activation associated protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418165.1NP_001405094.1  cytoglobin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL607039
    UniProtKB/TrEMBL
    Q8BN80
  2. NM_030206.5NP_084482.1  cytoglobin isoform 1

    See identical proteins and their annotated locations for NP_084482.1

    Status: VALIDATED

    Source sequence(s)
    AL607039
    Consensus CDS
    CCDS25673.1
    UniProtKB/Swiss-Prot
    Q9CX80
    UniProtKB/TrEMBL
    Q546K1, Q8BN80
    Related
    ENSMUSP00000021166.6, ENSMUST00000021166.6
    Conserved Domains (1) summary
    cd08924
    Location:22171
    Cygb; Cytoglobin and related globins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    116536421..116544887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)