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CYGB cytoglobin [ Homo sapiens (human) ]

Gene ID: 114757, updated on 23-Dec-2018

Summary

Official Symbol
CYGBprovided by HGNC
Official Full Name
cytoglobinprovided by HGNC
Primary source
HGNC:HGNC:16505
See related
Ensembl:ENSG00000161544 MIM:608759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HGB; STAP
Summary
This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in fat (RPKM 16.5), urinary bladder (RPKM 7.0) and 23 other tissues See more
Orthologs

Genomic context

See CYGB in Genome Data Viewer
Location:
17q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (76527348..76557692, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74523430..74533987, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene aralkylamine N-acetyltransferase Neighboring gene rhomboid 5 homolog 2 Neighboring gene photoreceptor disc component Neighboring gene small nucleolar RNA, C/D box 1C Neighboring gene small nucleolar RNA host gene 16 Neighboring gene small nucleolar RNA, C/D box 1B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of nitric oxide, organism-specific biosystem (from REACTOME)
    Metabolism of nitric oxide, organism-specific biosystemNitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blo...
  • eNOS activation, organism-specific biosystem (from REACTOME)
    eNOS activation, organism-specific biosystemeNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localizat...
  • eNOS activation and regulation, organism-specific biosystem (from REACTOME)
    eNOS activation and regulation, organism-specific biosystemOriginally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalase activity IEA
Inferred from Electronic Annotation
more info
 
fatty acid peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
nitric oxide dioxygenase activity TAS
Traceable Author Statement
more info
 
oxygen binding IEA
Inferred from Electronic Annotation
more info
 
oxygen carrier activity NAS
Non-traceable Author Statement
more info
PubMed 
peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hepatic stellate cell activation IEA
Inferred from Electronic Annotation
more info
 
oxygen transport NAS
Non-traceable Author Statement
more info
PubMed 
oxygen transport TAS
Traceable Author Statement
more info
 
regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytoglobin
Names
histoglobin
stellate cell activation-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134268.5NP_599030.1  cytoglobin

    See identical proteins and their annotated locations for NP_599030.1

    Status: VALIDATED

    Source sequence(s)
    AI470692, AK098057, BQ881744
    Consensus CDS
    CCDS11746.1
    UniProtKB/Swiss-Prot
    Q8WWM9
    UniProtKB/TrEMBL
    A0A1K0FUB6
    Related
    ENSP00000293230.4, ENST00000293230.9
    Conserved Domains (1) summary
    cd08924
    Location:22171
    Cygb; Cytoglobin and related globins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    76527348..76557692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024116.1XP_016879605.1  cytoglobin isoform X2

    Conserved Domains (1) summary
    cl21461
    Location:1106
    Globin_like; Globin-like proteins
  2. XM_005257005.3XP_005257062.1  cytoglobin isoform X1

    Conserved Domains (1) summary
    cd08924
    Location:22171
    Cygb; Cytoglobin and related globins
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