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TMEM200A transmembrane protein 200A [ Homo sapiens (human) ]

Gene ID: 114801, updated on 11-Jun-2021

Summary

Official Symbol
TMEM200Aprovided by HGNC
Official Full Name
transmembrane protein 200Aprovided by HGNC
Primary source
HGNC:HGNC:21075
See related
Ensembl:ENSG00000164484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTMA; TTMC; KIAA1913
Expression
Broad expression in endometrium (RPKM 12.2), adrenal (RPKM 5.0) and 16 other tissues See more
Orthologs
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Genomic context

See TMEM200A in Genome Data Viewer
Location:
6q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (130366017..130443424)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (130687162..130764212)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 3 Neighboring gene uncharacterized LOC105378000 Neighboring gene sterile alpha motif domain containing 3 Neighboring gene uncharacterized LOC112267974 Neighboring gene uncharacterized LOC105378002 Neighboring gene uncharacterized LOC105378003

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1913

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 200A
Names
two transmembrane C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258276.2NP_001245205.1  transmembrane protein 200A

    See identical proteins and their annotated locations for NP_001245205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AB052099, AK315824, AL121947, DA657363
    Consensus CDS
    CCDS5140.1
    UniProtKB/Swiss-Prot
    Q86VY9
    UniProtKB/TrEMBL
    A8K2A1
    Related
    ENSP00000480294.1, ENST00000617887.4
    Conserved Domains (1) summary
    pfam10177
    Location:16161
    DUF2371; Uncharacterized conserved protein (DUF2371)
  2. NM_001258277.2NP_001245206.1  transmembrane protein 200A

    See identical proteins and their annotated locations for NP_001245206.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AB052099, AB067500, AL121947
    Consensus CDS
    CCDS5140.1
    UniProtKB/Swiss-Prot
    Q86VY9
    UniProtKB/TrEMBL
    A8K2A1
    Related
    ENSP00000296978.3, ENST00000296978.4
    Conserved Domains (1) summary
    pfam10177
    Location:16161
    DUF2371; Uncharacterized conserved protein (DUF2371)
  3. NM_001258278.2NP_001245207.1  transmembrane protein 200A

    See identical proteins and their annotated locations for NP_001245207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents the use of an alternate promoter, compared to variant 1.
    Source sequence(s)
    AB052099, AL137185, DA164344
    Consensus CDS
    CCDS5140.1
    UniProtKB/Swiss-Prot
    Q86VY9
    UniProtKB/TrEMBL
    A8K2A1
    Related
    ENSP00000438928.1, ENST00000545622.5
    Conserved Domains (1) summary
    pfam10177
    Location:16161
    DUF2371; Uncharacterized conserved protein (DUF2371)
  4. NM_052913.3NP_443145.1  transmembrane protein 200A

    See identical proteins and their annotated locations for NP_443145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and represents the use of an alternate promoter, compared to variant 1.
    Source sequence(s)
    AB052099, AL137251
    Consensus CDS
    CCDS5140.1
    UniProtKB/Swiss-Prot
    Q86VY9
    UniProtKB/TrEMBL
    A8K2A1
    Related
    ENSP00000376224.1, ENST00000392429.1
    Conserved Domains (1) summary
    pfam10177
    Location:16161
    DUF2371; Uncharacterized conserved protein (DUF2371)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    130366017..130443424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266816.3XP_005266873.1  transmembrane protein 200A isoform X1

    See identical proteins and their annotated locations for XP_005266873.1

    UniProtKB/Swiss-Prot
    Q86VY9
    UniProtKB/TrEMBL
    A8K2A1
    Conserved Domains (1) summary
    pfam10177
    Location:16161
    DUF2371; Uncharacterized conserved protein (DUF2371)
  2. XM_011535419.2XP_011533721.1  transmembrane protein 200A isoform X1

    See identical proteins and their annotated locations for XP_011533721.1

    UniProtKB/Swiss-Prot
    Q86VY9
    UniProtKB/TrEMBL
    A8K2A1
    Conserved Domains (1) summary
    pfam10177
    Location:16161
    DUF2371; Uncharacterized conserved protein (DUF2371)
  3. XM_017010230.2XP_016865719.1  transmembrane protein 200A isoform X1

    UniProtKB/Swiss-Prot
    Q86VY9
    UniProtKB/TrEMBL
    A8K2A1
    Conserved Domains (1) summary
    pfam10177
    Location:16161
    DUF2371; Uncharacterized conserved protein (DUF2371)
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