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TMEM132B transmembrane protein 132B [ Homo sapiens (human) ]

Gene ID: 114795, updated on 17-Jun-2019

Summary

Official Symbol
TMEM132Bprovided by HGNC
Official Full Name
transmembrane protein 132Bprovided by HGNC
Primary source
HGNC:HGNC:29397
See related
Ensembl:ENSG00000139364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 6.4), thyroid (RPKM 1.0) and 2 other tissues See more
Orthologs

Genomic context

See TMEM132B in Genome Data Viewer
Location:
12q24.31-q24.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (125186386..125662377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125811162..126146915)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370052 Neighboring gene uncharacterized LOC105370053 Neighboring gene acetoacetyl-CoA synthetase Neighboring gene uncharacterized LOC105370054 Neighboring gene uncharacterized LOC107984445 Neighboring gene Sharpr-MPRA regulatory region 9406 Neighboring gene uncharacterized LOC105370055 Neighboring gene CTAGE family member 9 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37467, KIAA1786, KIAA1906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286219.1NP_001273148.1  transmembrane protein 132B isoform b

    See identical proteins and their annotated locations for NP_001273148.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple 5' coding exons, and contains an alternate 5' terminal exon, compared to variant 1. It initiates translation at a downstream in-frame start codon. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC005146, BC113366, HY012039
    Consensus CDS
    CCDS66501.1
    UniProtKB/Swiss-Prot
    Q14DG7
    Related
    ENSP00000482788.1, ENST00000613307.1
    Conserved Domains (2) summary
    pfam15706
    Location:382465
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:1282
    TMEM132; Transmembrane protein family 132
  2. NM_001366854.1NP_001353783.1  transmembrane protein 132B isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC004806, AC005146, AC026370, AC093028
    Conserved Domains (3) summary
    pfam15705
    Location:46174
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:875956
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:434775
    TMEM132; Transmembrane protein family 132
  3. NM_052907.3NP_443139.2  transmembrane protein 132B isoform a

    See identical proteins and their annotated locations for NP_443139.2

    Status: VALIDATED

    Source sequence(s)
    AB058689, AC005146, AC026370, AC093028, AK093097
    Consensus CDS
    CCDS41859.1
    UniProtKB/Swiss-Prot
    Q14DG7
    Related
    ENSP00000299308.3, ENST00000299308.7
    Conserved Domains (3) summary
    pfam15705
    Location:41170
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:870953
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:429770
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    125186386..125662377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018767.1XP_016874256.1  transmembrane protein 132B isoform X2

  2. XM_011537854.2XP_011536156.1  transmembrane protein 132B isoform X3

    See identical proteins and their annotated locations for XP_011536156.1

    UniProtKB/Swiss-Prot
    Q14DG7
    Conserved Domains (2) summary
    pfam15706
    Location:382465
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:1282
    TMEM132; Transmembrane protein family 132
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