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XKR4 XK related 4 [ Homo sapiens (human) ]

Gene ID: 114786, updated on 5-Jan-2022

Summary

Official Symbol
XKR4provided by HGNC
Official Full Name
XK related 4provided by HGNC
Primary source
HGNC:HGNC:29394
See related
Ensembl:ENSG00000206579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XRG4; hXKR4
Summary
Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in brain (RPKM 2.2), colon (RPKM 0.4) and 8 other tissues See more
Orthologs
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Genomic context

See XKR4 in Genome Data Viewer
Location:
8q12.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (55102028..55542054)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (56014588..56454613)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986944 Neighboring gene uncharacterized LOC107986886 Neighboring gene uncharacterized LOC107986887 Neighboring gene uncharacterized LOC105375844 Neighboring gene SET binding factor 1 pseudogene 1 Neighboring gene XKR4 antisense RNA 1 Neighboring gene uncharacterized LOC105375845 Neighboring gene uncharacterized LOC105375846

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
EBI GWAS Catalog
Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of XK, Kell blood group complex subunit-related family, member 4 (XKR4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1889

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic process involved in development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylserine exposure on apoptotic cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
XK-related protein 4
Names
X Kell blood group precursor-related family, member 4
X-linked Kx blood group related 4
XK, Kell blood group complex subunit-related family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052898.2NP_443130.1  XK-related protein 4

    See identical proteins and their annotated locations for NP_443130.1

    Status: VALIDATED

    Source sequence(s)
    AC022679, AC090200, AY534241
    Consensus CDS
    CCDS34893.1
    UniProtKB/Swiss-Prot
    Q5GH76
    Related
    ENSP00000328326.5, ENST00000327381.7
    Conserved Domains (1) summary
    pfam09815
    Location:117516
    XK-related; XK-related protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    55102028..55542054
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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