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CARD16 caspase recruitment domain family member 16 [ Homo sapiens (human) ]

Gene ID: 114769, updated on 5-Jan-2022

Summary

Official Symbol
CARD16provided by HGNC
Official Full Name
caspase recruitment domain family member 16provided by HGNC
Primary source
HGNC:HGNC:33701
See related
Ensembl:ENSG00000204397 MIM:615680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COP; COP1; PSEUDO-ICE; LLID-114769
Summary
Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in spleen (RPKM 14.0), appendix (RPKM 12.0) and 23 other tissues See more
Orthologs
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Genomic context

See CARD16 in Genome Data Viewer
Location:
11q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (105040218..105045416, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (104912053..104916062, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11455 Neighboring gene caspase 5 Neighboring gene caspase 1 Neighboring gene uncharacterized LOC107984381 Neighboring gene caspase 1 pseudogene 2 Neighboring gene caspase recruitment domain family member 17 Neighboring gene caspase 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of caspase recruitment domain family, member 16 (CARD16; COP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of protease inhibitor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 16
Names
CARD only domain-containing protein 1
CARD only protein
CARD-only protein 1
caspase recruitment domain-only protein 1
caspase-1 dominant-negative inhibitor pseudo-ICE
caspase-1 inhibitor COP
pseudo interleukin-1 beta converting enzyme
pseudo interleukin-1beta converting enzyme
pseudo-IL1B-converting enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394580.1NP_001381509.1  caspase recruitment domain-containing protein 16 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001153
    Conserved Domains (1) summary
    cd08325
    Location:171
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
  2. NM_052889.4NP_443121.1  caspase recruitment domain-containing protein 16 isoform 2

    See identical proteins and their annotated locations for NP_443121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AP001153
    Consensus CDS
    CCDS41705.1
    UniProtKB/Swiss-Prot
    Q5EG05
    Related
    ENSP00000509408.1, ENST00000673097.2
    Conserved Domains (1) summary
    cd08325
    Location:587
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    105040218..105045416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542583.2XP_011540885.1  caspase recruitment domain-containing protein 16 isoform X1

    Conserved Domains (1) summary
    cd08325
    Location:73155
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_024408.1: Suppressed sequence

    Description
    NG_024408.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
  2. NM_001017534.2: Suppressed sequence

    Description
    NM_001017534.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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