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CARD16 caspase recruitment domain family member 16 [ Homo sapiens (human) ]

Gene ID: 114769, updated on 24-Nov-2020

Summary

Official Symbol
CARD16provided by HGNC
Official Full Name
caspase recruitment domain family member 16provided by HGNC
Primary source
HGNC:HGNC:33701
See related
Ensembl:ENSG00000204397 MIM:615680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COP; COP1; PSEUDO-ICE
Expression
Broad expression in spleen (RPKM 14.0), appendix (RPKM 12.0) and 23 other tissues See more
Orthologs

Genomic context

See CARD16 in Genome Data Viewer
Location:
11q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (105040218..105045416, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (104912053..104916051, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene caspase 5 Neighboring gene caspase 1 Neighboring gene uncharacterized LOC107984381 Neighboring gene caspase 1 pseudogene 2 Neighboring gene caspase recruitment domain family member 17 Neighboring gene caspase 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of caspase recruitment domain family, member 16 (CARD16; COP1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
caspase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
caspase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
protease inhibitor complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
caspase recruitment domain-containing protein 16
Names
CARD only domain-containing protein 1
CARD only protein
CARD-only protein 1
caspase recruitment domain-only protein 1
caspase-1 dominant-negative inhibitor pseudo-ICE
caspase-1 inhibitor COP
pseudo interleukin-1 beta converting enzyme
pseudo interleukin-1beta converting enzyme
pseudo-IL1B-converting enzyme

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017534.2NP_001017534.1  caspase recruitment domain-containing protein 16 isoform 1

    See identical proteins and their annotated locations for NP_001017534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AP001153, AY885669, BC070196
    Consensus CDS
    CCDS31661.1
    UniProtKB/Swiss-Prot
    Q5EG05
    Related
    ENSP00000364858.2, ENST00000375706.7
    Conserved Domains (1) summary
    cd08325
    Location:587
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
  2. NM_052889.3NP_443121.1  caspase recruitment domain-containing protein 16 isoform 2

    See identical proteins and their annotated locations for NP_443121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon containing a stop codon in the middle region, as compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP001153, AY885669, BC070196
    Consensus CDS
    CCDS41705.1
    UniProtKB/Swiss-Prot
    Q5EG05
    Related
    ENSP00000364856.3, ENST00000375704.8
    Conserved Domains (1) summary
    cd08325
    Location:587
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    105040218..105045416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542583.2XP_011540885.1  caspase recruitment domain-containing protein 16 isoform X1

    Conserved Domains (1) summary
    cd08325
    Location:73155
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_024408.1: Suppressed sequence

    Description
    NG_024408.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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