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Impa2 inositol monophosphatase 2 [ Mus musculus (house mouse) ]

Gene ID: 114663, updated on 12-May-2024

Summary

Official Symbol
Impa2provided by MGI
Official Full Name
inositol monophosphatase 2provided by MGI
Primary source
MGI:MGI:2149728
See related
Ensembl:ENSMUSG00000024525 AllianceGenome:MGI:2149728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IMP 2; IMPase 2; 2210415D20Rik
Summary
Predicted to enable inositol monophosphate 1-phosphatase activity and protein homodimerization activity. Predicted to be involved in inositol metabolic process; inositol phosphate dephosphorylation; and signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.6), limb E14.5 (RPKM 11.5) and 28 other tissues See more
Orthologs
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Genomic context

See Impa2 in Genome Data Viewer
Location:
18 E1; 18 39.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67422246..67454375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67289247..67319216)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha stimulating, olfactory type Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:67372131-67372603 Neighboring gene charged multivesicular body protein 1B Neighboring gene STARR-positive B cell enhancer ABC_E9173 Neighboring gene metallophosphoesterase 1 Neighboring gene STARR-seq mESC enhancer starr_44880 Neighboring gene STARR-positive B cell enhancer ABC_E7602 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67448542-67448843 Neighboring gene STARR-seq mESC enhancer starr_44887 Neighboring gene predicted gene, 30321 Neighboring gene RIKEN cDNA B430212C06 gene Neighboring gene STARR-positive B cell enhancer ABC_E10999 Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector A Neighboring gene tubulin, beta 6 class V

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol monophosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables inositol monophosphate 1-phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables inositol monophosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol monophosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inositol metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lithium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
inositol monophosphatase 2
Names
inositol (myo)-1(or 4)-monophosphatase 2
myo-inositol monophosphatase A2
NP_444491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053261.3NP_444491.1  inositol monophosphatase 2

    See identical proteins and their annotated locations for NP_444491.1

    Status: VALIDATED

    Source sequence(s)
    AC154125
    Consensus CDS
    CCDS29320.1
    UniProtKB/Swiss-Prot
    Q91UZ5
    UniProtKB/TrEMBL
    Q3TAU6, Q3U3B7
    Related
    ENSMUSP00000025403.7, ENSMUST00000025403.8
    Conserved Domains (1) summary
    cd01639
    Location:21266
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    67422246..67454375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939813.1 RNA Sequence