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IMPA2 inositol monophosphatase 2 [ Homo sapiens (human) ]

Gene ID: 3613, updated on 24-Nov-2020

Summary

Official Symbol
IMPA2provided by HGNC
Official Full Name
inositol monophosphatase 2provided by HGNC
Primary source
HGNC:HGNC:6051
See related
Ensembl:ENSG00000141401 MIM:605922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Expression
Broad expression in kidney (RPKM 73.3), skin (RPKM 38.8) and 18 other tissues See more
Orthologs

Genomic context

See IMPA2 in Genome Data Viewer
Location:
18p11.21
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (11981465..12030878)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (11981427..12030885)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha L Neighboring gene uncharacterized LOC101927511 Neighboring gene metallophosphoesterase 1 Neighboring gene CRISPRi-validated cis-regulatory element chr18.397 Neighboring gene kinesin-like protein KIF1C pseudogene Neighboring gene single stranded DNA binding protein 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inositol monophosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol monophosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
inositol monophosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
inositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inositol phosphate dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
inositol monophosphatase 2
Names
IMP 2
IMPase 2
inosine monophosphatase 2
inositol monophosphatase 2 variant 1
inositol monophosphatase 2 variant 2
inositol(myo)-1(or 4)-monophosphatase 2
myo-inositol monophosphatase 2
myo-inositol monophosphatase A2
NP_055029.1
XP_011523961.1
XP_011523963.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028104.1 RefSeqGene

    Range
    5052..54422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014214.3NP_055029.1  inositol monophosphatase 2

    See identical proteins and their annotated locations for NP_055029.1

    Status: REVIEWED

    Source sequence(s)
    AP001269, BC017176
    Consensus CDS
    CCDS11855.1
    UniProtKB/Swiss-Prot
    O14732
    Related
    ENSP00000269159.3, ENST00000269159.8
    Conserved Domains (1) summary
    cd01639
    Location:19265
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    11981465..12030878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525661.3XP_011523963.1  inositol monophosphatase 2 isoform X2

    Conserved Domains (1) summary
    cl00289
    Location:8145
    FIG; FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in ...
  2. XM_011525659.3XP_011523961.1  inositol monophosphatase 2 isoform X1

    Conserved Domains (1) summary
    cd01639
    Location:62249
    IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
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