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Chrna1 cholinergic receptor nicotinic alpha 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 11435, updated on 12-May-2024

Summary

Official Symbol
Chrna1provided by MGI
Official Full Name
cholinergic receptor nicotinic alpha 1 subunitprovided by MGI
Primary source
MGI:MGI:87885
See related
Ensembl:ENSMUSG00000027107 AllianceGenome:MGI:87885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acra; Achr-1
Summary
This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]
Expression
Biased expression in limb E14.5 (RPKM 3.2), testis adult (RPKM 1.0) and 4 other tissues See more
Orthologs
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Genomic context

See Chrna1 in Genome Data Viewer
Location:
2 C3; 2 43.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73393625..73410682, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73563281..73580338, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13707 Neighboring gene WAS/WASL interacting protein family, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E2623 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73288549-73288732 Neighboring gene STARR-positive B cell enhancer ABC_E4467 Neighboring gene STARR-positive B cell enhancer ABC_E1245 Neighboring gene STARR-positive B cell enhancer ABC_E5934 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:73324434-73324587 Neighboring gene STARR-positive B cell enhancer ABC_E2038 Neighboring gene predicted gene, 54162 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73378889-73379190 Neighboring gene STARR-positive B cell enhancer ABC_E10115 Neighboring gene predicted gene, 30940 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit, opposite strand Neighboring gene predicted gene, 53265

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nicotine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of acetylcholine-gated channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
acetylcholine receptor subunit alpha
Names
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007389.5NP_031415.2  acetylcholine receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_031415.2

    Status: REVIEWED

    Source sequence(s)
    AK029177, AL928813, AL928889
    Consensus CDS
    CCDS16132.1
    UniProtKB/Swiss-Prot
    P04756
    UniProtKB/TrEMBL
    Q05A24, Q3V1A2
    Related
    ENSMUSP00000028515.4, ENSMUST00000028515.4
    Conserved Domains (2) summary
    pfam02931
    Location:24231
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:238446
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    73393625..73410682 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)