U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acp1 acid phosphatase 1, soluble [ Mus musculus (house mouse) ]

Gene ID: 11431, updated on 8-Feb-2024

Summary

Official Symbol
Acp1provided by MGI
Official Full Name
acid phosphatase 1, solubleprovided by MGI
Primary source
MGI:MGI:87881
See related
Ensembl:ENSMUSG00000044573 AllianceGenome:MGI:87881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acp-1; Lmptp; LMW-PTP; 4632432E04Rik
Summary
Enables acid phosphatase activity. Predicted to be involved in protein dephosphorylation. Located in cytosol and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.9) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Acp1 in Genome Data Viewer
Location:
12 A2; 12 13.0 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30943325..30961616, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30893326..30911619, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11506 Neighboring gene transmembrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_31844 Neighboring gene predicted gene, 32320 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene ALK and LTK ligand 2 Neighboring gene Sh3 domain YSC-like 1 Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103115, MGC132904

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables acid phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acid phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
low molecular weight phosphotyrosine protein phosphatase
Names
LMW-PTPase
low molecular weight cytosolic acid phosphatase
NP_001103709.1
NP_067305.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110239.1NP_001103709.1  low molecular weight phosphotyrosine protein phosphatase isoform 1

    See identical proteins and their annotated locations for NP_001103709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1, also known as IF2).
    Source sequence(s)
    AC160932, AK014603, AK152429
    Consensus CDS
    CCDS49045.1
    UniProtKB/TrEMBL
    Q561M1
    Related
    ENSMUSP00000073686.6, ENSMUST00000074038.7
    Conserved Domains (1) summary
    cd16343
    Location:7155
    LMWPTP; Low molecular weight protein tyrosine phosphatase
  2. NM_021330.4NP_067305.2  low molecular weight phosphotyrosine protein phosphatase isoform 2

    See identical proteins and their annotated locations for NP_067305.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2, also known as IF1) is the same length as isoform 1 but differs at an internal region, compared to isoform 1.
    Source sequence(s)
    AC160932, AK082955
    Consensus CDS
    CCDS36427.1
    UniProtKB/Swiss-Prot
    O88739, O88740, Q9D358, Q9QWF5
    UniProtKB/TrEMBL
    Q4VAI2
    Related
    ENSMUSP00000106509.4, ENSMUST00000062740.15
    Conserved Domains (1) summary
    cd00115
    Location:7155
    LMWPc; Low molecular weight phosphatase family;

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    30943325..30961616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_381176.5 RNA Sequence