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ACP1 acid phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 52, updated on 9-Dec-2018

Summary

Official Symbol
ACP1provided by HGNC
Official Full Name
acid phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:122
See related
Ensembl:ENSG00000143727 MIM:171500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAAP; LMWPTP; LMW-PTP
Summary
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in adrenal (RPKM 48.0), kidney (RPKM 32.6) and 25 other tissues See more
Orthologs

Genomic context

See ACP1 in Genome Data Viewer
Location:
2p25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (264869..278283)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (264869..278283)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373324 Neighboring gene SH3 and SYLF domain containing 1 Neighboring gene melanoma-associated antigen C1-like Neighboring gene uncharacterized LOC105373346 Neighboring gene ALK and LTK ligand 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3499, MGC111030

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
low molecular weight phosphotyrosine protein phosphatase
Names
LMW-PTPase
acid phosphatase 1, soluble
acid phosphatase of erythrocyte
adipocyte acid phosphatase
cytoplasmic phosphotyrosyl protein phosphatase
low molecular weight cytosolic acid phosphatase
protein tyrosine phosphatase
red cell acid phosphatase 1
testicular secretory protein Li 37
NP_001035739.1
NP_004291.1
NP_009030.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012035.1 RefSeqGene

    Range
    5001..18415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040649.2NP_001035739.1  low molecular weight phosphotyrosine protein phosphatase isoform d

    See identical proteins and their annotated locations for NP_001035739.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the shortest transcript and encodes the shortest isoform (d).
    Source sequence(s)
    AC079779, DA378283
    Consensus CDS
    CCDS46217.1
    UniProtKB/TrEMBL
    A0A140VK37
    Related
    ENSP00000385404.3, ENST00000407983.7
    Conserved Domains (1) summary
    cd16343
    Location:784
    LMWPTP; Low molecular weight protein tyrosine phosphatase
  2. NM_004300.4NP_004291.1  low molecular weight phosphotyrosine protein phosphatase isoform c

    See identical proteins and their annotated locations for NP_004291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 4. The resulting protein (isoform c, also known as Bf) has a distinct C-terminus and is longer than isoform d.
    Source sequence(s)
    AB209838, BX481618, DB443811
    Consensus CDS
    CCDS1639.1
    UniProtKB/Swiss-Prot
    P24666
    UniProtKB/TrEMBL
    Q59EH3
    Related
    ENSP00000272065.5, ENST00000272065.9
    Conserved Domains (1) summary
    cd16343
    Location:7155
    LMWPTP; Low molecular weight protein tyrosine phosphatase
  3. NM_007099.3NP_009030.1  low molecular weight phosphotyrosine protein phosphatase isoform b

    See identical proteins and their annotated locations for NP_009030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 4, one of which results in a translational frameshift. The resulting protein (isoform b, also known as Bs) has a distinct C-terminus and is longer than isoform d.
    Source sequence(s)
    AC079779, BC007422, BX481618, M83654
    Consensus CDS
    CCDS1640.1
    UniProtKB/Swiss-Prot
    P24666
    Related
    ENSP00000272067.6, ENST00000272067.10
    Conserved Domains (1) summary
    cd16343
    Location:7155
    LMWPTP; Low molecular weight protein tyrosine phosphatase

RNA

  1. NR_024080.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region, compared to variant 4, one of which results in a frameshift with an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is truncated and the transcript is a candidate for nonsense-mediated decay (NMD).
    Source sequence(s)
    AB209838, AC079779, BJ992018, BX481618

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    264869..278283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001738777.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177554.1: Suppressed sequence

    Description
    NM_177554.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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