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Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 [ Mus musculus (house mouse) ]

Gene ID: 11421, updated on 19-Mar-2019

Summary

Official Symbol
Aceprovided by MGI
Official Full Name
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1provided by MGI
Primary source
MGI:MGI:87874
See related
Ensembl:ENSMUSG00000020681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD143; AW208573
Expression
Biased expression in lung adult (RPKM 304.6), duodenum adult (RPKM 225.6) and 6 other tissues See more
Orthologs

Genomic context

See Ace in Genome Data Viewer
Location:
11 E1; 11 68.84 cM
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (105967945..105989964)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (105829261..105851259)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 46296 Neighboring gene cytochrome b-561 Neighboring gene predicted gene 11651 Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representatio...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
    Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117827

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding ISO
Inferred from Sequence Orthology
more info
 
bradykinin receptor binding ISO
Inferred from Sequence Orthology
more info
 
carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
chloride ion binding ISO
Inferred from Sequence Orthology
more info
 
dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug binding ISO
Inferred from Sequence Orthology
more info
 
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
exopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallodipeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-dipeptidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tripeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
amyloid-beta metabolic process ISO
Inferred from Sequence Orthology
more info
 
angiogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
animal organ regeneration ISO
Inferred from Sequence Orthology
more info
 
arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
 
cell proliferation in bone marrow IMP
Inferred from Mutant Phenotype
more info
PubMed 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
 
heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hormone catabolic process ISO
Inferred from Sequence Orthology
more info
 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel diameter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gap junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
neutrophil mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
peptide metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-cysteine S-nitrosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of angiotensin metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of systemic arterial blood pressure by renin-angiotensin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of systemic arterial blood pressure by renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sperm midpiece ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
angiotensin-converting enzyme
Names
dipeptidyl carboxypeptidase I
dipeptidyl peptidase
kininase II
NP_001268748.1
NP_033728.1
NP_997507.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281819.1NP_001268748.1  angiotensin-converting enzyme isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK161020, AK164780, AL731865, BY210311
    UniProtKB/TrEMBL
    Q3TU20
    Related
    ENSMUSP00000119826.1, ENSMUST00000132280.7
    Conserved Domains (1) summary
    pfam01401
    Location:6491226
    Peptidase_M2; Angiotensin-converting enzyme
  2. NM_009598.2NP_033728.1  angiotensin-converting enzyme isoform 2 precursor

    See identical proteins and their annotated locations for NP_033728.1

    Status: VALIDATED

    Description
    Transcript Variant: The variant (2) differs in the 5' UTR and lacks multiple 5' coding exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK164780, AL731865, M55333
    Consensus CDS
    CCDS25544.1
    UniProtKB/Swiss-Prot
    P09470
    Related
    ENSMUSP00000001964.7, ENSMUST00000001964.7
    Conserved Domains (1) summary
    pfam01401
    Location:69646
    Peptidase_M2; Angiotensin-converting enzyme
  3. NM_207624.5NP_997507.1  angiotensin-converting enzyme isoform 1 precursor

    See identical proteins and their annotated locations for NP_997507.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK161020, AL731865, BY210311
    Consensus CDS
    CCDS25543.1
    UniProtKB/Swiss-Prot
    P09470
    UniProtKB/TrEMBL
    Q3TU20
    Related
    ENSMUSP00000001963.7, ENSMUST00000001963.13
    Conserved Domains (1) summary
    pfam01401
    Location:6491226
    Peptidase_M2; Angiotensin-converting enzyme

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    105967945..105989964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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