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Ace angiotensin I converting enzyme [ Mus musculus (house mouse) ]

Gene ID: 11421, updated on 1-Mar-2024

Summary

Official Symbol
Aceprovided by MGI
Official Full Name
angiotensin I converting enzymeprovided by MGI
Primary source
MGI:MGI:87874
See related
Ensembl:ENSMUSG00000020681 AllianceGenome:MGI:87874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD143
Summary
Enables metallopeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including cell proliferation in bone marrow; positive regulation of protein modification process; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 304.6), duodenum adult (RPKM 225.6) and 6 other tissues See more
Orthologs
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Genomic context

See Ace in Genome Data Viewer
Location:
11 E1; 11 68.84 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105858774..105880790)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105967948..105989964)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene STARR-seq mESC enhancer starr_30910 Neighboring gene predicted gene, 53650 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene cytochrome b-561 Neighboring gene predicted gene 9910 Neighboring gene predicted gene 11651 Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme 3 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117827

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables bradykinin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables chloride ion binding ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallodipeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-dipeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidyl-dipeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tripeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiotensin maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiotensin maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiotensin maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in angiotensin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in animal organ regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in bradykinin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell proliferation in bone marrow IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hormone catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gap junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-cysteine S-nitrosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of angiotensin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic plasticity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of systemic arterial blood pressure by renin-angiotensin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of systemic arterial blood pressure by renin-angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substance P catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
angiotensin-converting enzyme
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
dipeptidyl carboxypeptidase I
dipeptidyl peptidase
kininase II
NP_001268748.1
NP_033728.1
NP_997507.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281819.2NP_001268748.1  angiotensin-converting enzyme isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL596246, AL731865
    UniProtKB/TrEMBL
    Q5XK22
    Related
    ENSMUSP00000119826.2, ENSMUST00000132280.8
    Conserved Domains (1) summary
    pfam01401
    Location:6491226
    Peptidase_M2; Angiotensin-converting enzyme
  2. NM_009598.3NP_033728.1  angiotensin-converting enzyme isoform 2 precursor

    See identical proteins and their annotated locations for NP_033728.1

    Status: VALIDATED

    Source sequence(s)
    AL596246, AL731865
    Consensus CDS
    CCDS25544.1
    UniProtKB/Swiss-Prot
    P09470
    Related
    ENSMUSP00000001964.8, ENSMUST00000001964.8
    Conserved Domains (1) summary
    pfam01401
    Location:69646
    Peptidase_M2; Angiotensin-converting enzyme
  3. NM_207624.6NP_997507.1  angiotensin-converting enzyme isoform 1 precursor

    See identical proteins and their annotated locations for NP_997507.1

    Status: VALIDATED

    Source sequence(s)
    AL596246, AL731865
    Consensus CDS
    CCDS25543.1
    UniProtKB/Swiss-Prot
    P09470, P22967, Q6GTS2
    UniProtKB/TrEMBL
    Q3TU20, Q3U3Q7
    Related
    ENSMUSP00000001963.8, ENSMUST00000001963.14
    Conserved Domains (1) summary
    pfam01401
    Location:6491226
    Peptidase_M2; Angiotensin-converting enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105858774..105880790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)