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TXNRD3 thioredoxin reductase 3 [ Homo sapiens (human) ]

Gene ID: 114112, updated on 1-Jun-2020

Summary

Official Symbol
TXNRD3provided by HGNC
Official Full Name
thioredoxin reductase 3provided by HGNC
Primary source
HGNC:HGNC:20667
See related
Ensembl:ENSG00000197763 MIM:606235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGR; TR2; TRXR3; TR2IT1; TXNRD3NB; TXNRD3IT1; TXNRD3NT1
Summary
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Experimental evidence suggests the use of a non-AUG (CUG) codon as a translation initiation codon (PMID:20018845). [provided by RefSeq, Aug 2017]
Expression
Broad expression in testis (RPKM 13.6), thyroid (RPKM 4.0) and 21 other tissues See more
Orthologs

Genomic context

See TXNRD3 in Genome Data Viewer
Location:
3q21.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (126607059..126655124, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (126325895..126375056, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene chromosome 3 open reading frame 22 Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene uncharacterized LOC105374090 Neighboring gene RNA, 5S ribosomal pseudogene 138 Neighboring gene methyltransferase like 5 pseudogene Neighboring gene nucleoporin 210 pseudogene 1 Neighboring gene splicing factor 3a subunit 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163418, MGC163420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
thioredoxin-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thioredoxin-disulfide reductase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell redox homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
thioredoxin reductase 3
Names
TXNRD3 neighbor gene protein
thioredoxin and glutathione reductase
thioredoxin glutathione reductase
thioredoxin reductase 2
thioredoxin reductase 2 intronic transcript 1
thioredoxin reductase 3 intronic transcript 1
thioredoxin reductase 3 neighbor
thioredoxin reductase 3 neighbor gene protein
thioredoxin reductase 3 new transcript 1
thioredoxin reductase TR2
NP_001166984.1
NP_443115.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173513.2NP_001166984.1  thioredoxin reductase 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, which results in a shorter isoform (2) missing an internal protein segment compared to isoform 1. A non-AUG (CUG) codon is used as translation initiation codon.
    Source sequence(s)
    AC024558
    Consensus CDS
    CCDS77810.1
    UniProtKB/Swiss-Prot
    Q86VQ6
    UniProtKB/TrEMBL
    B4DRZ5
    Related
    ENSP00000429584.2, ENST00000523403.2
    Conserved Domains (4) summary
    cd03419
    Location:67148
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    TIGR01438
    Location:155607
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:336412
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:508589
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
  2. NM_052883.2NP_443115.1  thioredoxin reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_443115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). A non-AUG (CUG) codon is used as translation initiation codon.
    Source sequence(s)
    AC024558
    Consensus CDS
    CCDS77811.1
    UniProtKB/Swiss-Prot
    Q86VQ6
    Related
    ENSP00000430031.3, ENST00000524230.7
    Conserved Domains (4) summary
    cd03419
    Location:67148
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
    TIGR01438
    Location:155643
    TGR; thioredoxin and glutathione reductase selenoprotein
    pfam00070
    Location:336412
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:515625
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    126607059..126655124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039783.1: Suppressed sequence

    Description
    NM_001039783.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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