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Gucy2d guanylate cyclase 2d [ Rattus norvegicus (Norway rat) ]

Gene ID: 113911, updated on 21-Dec-2019

Summary

Official Symbol
Gucy2dprovided by RGD
Official Full Name
guanylate cyclase 2dprovided by RGD
Primary source
RGD:69322
See related
Ensembl:ENSRNOG00000015058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GC-D; ONE-GC
Summary
member of the membrane receptor guanyly cyclase family, specifically expressed in a subpopulation of olfactory sensory neurons; may function directly in odor recognition [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 3.8), Muscle (RPKM 0.9) and 2 other tissues See more
Orthologs

Genomic context

See Gucy2d in Genome Data Viewer
Location:
1q32
Exon count:
19
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (163398891..163433594)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (150829240..150863848)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (169603078..169637802)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349448 Neighboring gene similar to thioredoxin Neighboring gene leucine rich repeat containing 32 Neighboring gene similar to Tubulin alpha-6 chain (Alpha-tubulin 6)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
natriuretic peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
guanylate cyclase 2D; olfactory guanylyl cyclase GC-D
Names
guanylate cyclase, olfactory
NP_570093.1
XP_006229772.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130737.4NP_570093.1  guanylate cyclase 2D

    See identical proteins and their annotated locations for NP_570093.1

    Status: PROVISIONAL

    Source sequence(s)
    L37203
    UniProtKB/Swiss-Prot
    P51839
    Related
    ENSRNOP00000020513.6, ENSRNOT00000020513.6
    Conserved Domains (6) summary
    cd06371
    Location:71445
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:8611050
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:554824
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam00211
    Location:8841071
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:91422
    ANF_receptor; Receptor family ligand binding region
    pfam07714
    Location:575818
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    163398891..163433594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229710.1XP_006229772.1  olfactory guanylyl cyclase GC-D isoform X1

    See identical proteins and their annotated locations for XP_006229772.1

    Conserved Domains (6) summary
    cd06371
    Location:71445
    PBP1_sensory_GC_DEF_like; Ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    smart00044
    Location:8611050
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:554824
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    pfam00211
    Location:8841071
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:91422
    ANF_receptor; Receptor family ligand binding region
    pfam07714
    Location:575818
    Pkinase_Tyr; Protein tyrosine kinase

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    150829240..150863848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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