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TUSC2 tumor suppressor 2, mitochondrial calcium regulator [ Homo sapiens (human) ]

Gene ID: 11334, updated on 7-Jun-2020

Summary

Official Symbol
TUSC2provided by HGNC
Official Full Name
tumor suppressor 2, mitochondrial calcium regulatorprovided by HGNC
Primary source
HGNC:HGNC:17034
See related
Ensembl:ENSG00000114383 MIM:607052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP; FUS1; PDAP2; C3orf11
Summary
This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 15.7), kidney (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See TUSC2 in Genome Data Viewer
Location:
3p21.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50324909..50328238, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50362341..50365668, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hyaluronidase 1 Neighboring gene hyaluronidase 2 Neighboring gene Ras association domain family member 1 Neighboring gene RASSF1 antisense RNA 1 Neighboring gene zinc finger MYND-type containing 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
chemokine (C-C motif) ligand 5 production IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-15 production IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
neutrophil mediated killing of gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tumor suppressor candidate 2
Names
PDGFA-associated protein 2
fus-1 protein
fusion 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007275.2NP_009206.1  tumor suppressor candidate 2

    See identical proteins and their annotated locations for NP_009206.1

    Status: REVIEWED

    Source sequence(s)
    BC023976, CA392689
    Consensus CDS
    CCDS2819.1
    UniProtKB/Swiss-Prot
    O75896
    Related
    ENSP00000232496.4, ENST00000232496.5
    Conserved Domains (1) summary
    pfam15000
    Location:1109
    TUSC2; tumor suppressor candidate 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50324909..50328238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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