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Tusc2 tumor suppressor 2, mitochondrial calcium regulator [ Mus musculus (house mouse) ]

Gene ID: 80385, updated on 8-Feb-2024

Summary

Official Symbol
Tusc2provided by MGI
Official Full Name
tumor suppressor 2, mitochondrial calcium regulatorprovided by MGI
Primary source
MGI:MGI:1931086
See related
Ensembl:ENSMUSG00000010054 AllianceGenome:MGI:1931086
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAP; Fus1; Lgcc; Pdap2; 1190001E22Rik
Summary
Acts upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Located in mitochondrion. Is expressed in liver and metanephros. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 49.1), colon adult (RPKM 39.8) and 28 other tissues See more
Orthologs
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Genomic context

See Tusc2 in Genome Data Viewer
Location:
9 F1; 9 58.12 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107440454..107443307)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107563255..107566108)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger, MYND domain containing 10 Neighboring gene predicted gene, 34106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107453431-107453584 Neighboring gene STARR-positive B cell enhancer ABC_E9335 Neighboring gene Ras association (RalGDS/AF-6) domain family member 1 Neighboring gene predicted gene 9917 Neighboring gene STARR-positive B cell enhancer ABC_E2304 Neighboring gene hyaluronoglucosaminidase 2 Neighboring gene STARR-seq mESC enhancer starr_25176 Neighboring gene hyaluronoglucosaminidase 1 Neighboring gene N(alpha)-acetyltransferase 80, NatH catalytic subunit Neighboring gene hyaluronoglucosaminidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemokine (C-C motif) ligand 5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-15 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tumor suppressor candidate 2
Names
PDGFA associated protein 2
fus-1 protein
fusion 1 protein
lung cancer candidiate, FUS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019742.4NP_062716.1  tumor suppressor candidate 2

    See identical proteins and their annotated locations for NP_062716.1

    Status: PROVISIONAL

    Source sequence(s)
    AL672219
    Consensus CDS
    CCDS23495.1
    UniProtKB/Swiss-Prot
    Q9WVF8
    UniProtKB/TrEMBL
    A0A0A6YWP5, Q542N4
    Related
    ENSMUSP00000010198.4, ENSMUST00000010198.5
    Conserved Domains (1) summary
    pfam15000
    Location:1109
    TUSC2; tumor suppressor candidate 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107440454..107443307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)