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LYPLA2 lysophospholipase 2 [ Homo sapiens (human) ]

Gene ID: 11313, updated on 11-Jun-2021

Summary

Official Symbol
LYPLA2provided by HGNC
Official Full Name
lysophospholipase 2provided by HGNC
Primary source
HGNC:HGNC:6738
See related
Ensembl:ENSG00000011009 MIM:616143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APT2; APT-2; DJ886K2.4
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 17.1), duodenum (RPKM 15.8) and 25 other tissues See more
Orthologs
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Genomic context

See LYPLA2 in Genome Data Viewer
Location:
1p36.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (23790789..23795539)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24117635..24122029)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene elongin A Neighboring gene ELOA antisense RNA 1 Neighboring gene PITH domain containing 1 Neighboring gene uncharacterized LOC105376860 Neighboring gene UDP-galactose-4-epimerase Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axon guidance TAS
Traceable Author Statement
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 

General protein information

Preferred Names
acyl-protein thioesterase 2
Names
LPL-II
lysoPLA II
lysophospholipase II
testicular tissue protein Li 3
NP_009191.1
XP_005245785.1
XP_016855654.1
XP_024308564.1
XP_024308565.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007260.3NP_009191.1  acyl-protein thioesterase 2

    See identical proteins and their annotated locations for NP_009191.1

    Status: REVIEWED

    Source sequence(s)
    AL031295
    Consensus CDS
    CCDS241.1
    UniProtKB/Swiss-Prot
    O95372
    UniProtKB/TrEMBL
    A0A140VJC9
    Related
    ENSP00000363638.3, ENST00000374514.8
    Conserved Domains (1) summary
    pfam02230
    Location:11228
    Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    23790789..23795539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452796.1XP_024308564.1  acyl-protein thioesterase 2 isoform X1

    Conserved Domains (1) summary
    pfam02230
    Location:26284
    Abhydrolase_2; Phospholipase/Carboxylesterase
  2. XM_024452797.1XP_024308565.1  acyl-protein thioesterase 2 isoform X2

    Conserved Domains (1) summary
    pfam02230
    Location:14272
    Abhydrolase_2; Phospholipase/Carboxylesterase
  3. XM_017000165.1XP_016855654.1  acyl-protein thioesterase 2 isoform X4

  4. XM_005245728.5XP_005245785.1  acyl-protein thioesterase 2 isoform X3

    Conserved Domains (1) summary
    pfam02230
    Location:26240
    Abhydrolase_2; Phospholipase/Carboxylesterase
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