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Lypla2 lysophospholipase 2 [ Mus musculus (house mouse) ]

Gene ID: 26394, updated on 26-Sep-2022

Summary

Official Symbol
Lypla2provided by MGI
Official Full Name
lysophospholipase 2provided by MGI
Primary source
MGI:MGI:1347000
See related
Ensembl:ENSMUSG00000028670 AllianceGenome:MGI:1347000
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LysoII
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in prostaglandin catabolic process and protein depalmitoylation. Located in Golgi stack. Is expressed in several structures, including alimentary system; eye; integumental system; nervous system; and urinary system. Orthologous to human LYPLA2 (lysophospholipase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 103.7), duodenum adult (RPKM 82.5) and 28 other tissues See more
Orthologs
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Genomic context

See Lypla2 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135695535..135699923, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135968224..135972612, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Neighboring gene galactose-4-epimerase, UDP Neighboring gene PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 Neighboring gene predicted gene 13007

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
 
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein depalmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
acyl-protein thioesterase 2
Names
APT-2
LPL-II
lysoPLA II
lysophospholipase II
mLyso II
palmitoyl-protein hydrolase
NP_036072.1
XP_006538941.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011942.1NP_036072.1  acyl-protein thioesterase 2

    See identical proteins and their annotated locations for NP_036072.1

    Status: PROVISIONAL

    Source sequence(s)
    AB009653
    Consensus CDS
    CCDS18797.1
    UniProtKB/Swiss-Prot
    Q3TJD6, Q9WTL7
    UniProtKB/TrEMBL
    A0A6P5PJY2
    Related
    ENSMUSP00000064204.5, ENSMUST00000067567.5
    Conserved Domains (1) summary
    pfam02230
    Location:14228
    Abhydrolase_2; Phospholipase/Carboxylesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135695535..135699923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538878.3XP_006538941.1  acyl-protein thioesterase 2 isoform X1

    Conserved Domains (1) summary
    pfam02230
    Location:9177
    Abhydrolase_2; Phospholipase/Carboxylesterase