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GLMP glycosylated lysosomal membrane protein [ Homo sapiens (human) ]

Gene ID: 112770, updated on 12-Oct-2019

Summary

Official Symbol
GLMPprovided by HGNC
Official Full Name
glycosylated lysosomal membrane proteinprovided by HGNC
Primary source
HGNC:HGNC:29436
See related
Ensembl:ENSG00000198715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCU-G1; C1orf85
Expression
Ubiquitous expression in prostate (RPKM 30.2), placenta (RPKM 24.2) and 25 other tissues See more
Orthologs

Genomic context

See GLMP in Genome Data Viewer
Location:
1q22
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (156292687..156295689, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156262478..156265480, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PMF1-BGLAP readthrough Neighboring gene progestin and adipoQ receptor family member 6 Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene Sharpr-MPRA regulatory regions 9834 and 13552 Neighboring gene transmembrane protein 79 Neighboring gene VHL like Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene TSSK6 activating cochaperone

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC31963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glycosylated lysosomal membrane protein
Names
kidney lysosomal membrane protein
kidney predominant protein NCU-G1
lysosomal protein NCU-G1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256604.1NP_001243533.1  glycosylated lysosomal membrane protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BP302818, CA428514, CX756681, DA537642, N72839
    Conserved Domains (1) summary
    pfam15065
    Location:55328
    NCU-G1; Lysosomal transcription factor, NCU-G1
  2. NM_001256605.1NP_001243534.1  glycosylated lysosomal membrane protein isoform 3

    See identical proteins and their annotated locations for NP_001243534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL528533, BM833126, CA428514, DA537642, N72839
    Consensus CDS
    CCDS72948.1
    UniProtKB/TrEMBL
    A0A087WV34
    Related
    ENSP00000479149.1, ENST00000622703.4
    Conserved Domains (1) summary
    pfam15065
    Location:40291
    NCU-G1; Lysosomal transcription factor, NCU-G1
  3. NM_001256608.1NP_001243537.1  glycosylated lysosomal membrane protein isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AW293248, CN479212, CX756681, DA537642, N72839
    Consensus CDS
    CCDS72949.1
    UniProtKB/TrEMBL
    A0A087X0W3
    Related
    ENSP00000483691.1, ENST00000612353.4
    Conserved Domains (1) summary
    pfam15065
    Location:55267
    NCU-G1; Lysosomal transcription factor, NCU-G1
  4. NM_001256609.1NP_001243538.1  glycosylated lysosomal membrane protein isoform 5

    See identical proteins and their annotated locations for NP_001243538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK296157, CA428514, DA537642, N72839
    Consensus CDS
    CCDS72947.1
    UniProtKB/Swiss-Prot
    Q8WWB7
    Related
    ENSP00000480936.1, ENST00000614643.4
    Conserved Domains (1) summary
    pfam15065
    Location:1296
    NCU-G1; Lysosomal transcription factor, NCU-G1
  5. NM_144580.3NP_653181.1  glycosylated lysosomal membrane protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_653181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC018757, DA537642, N72839
    Consensus CDS
    CCDS1139.1
    UniProtKB/Swiss-Prot
    Q8WWB7
    Related
    ENSP00000354553.1, ENST00000362007.6
    Conserved Domains (1) summary
    pfam15065
    Location:55377
    NCU-G1; Lysosomal transcription factor, NCU-G1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    156292687..156295689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509117.3XP_011507419.1  glycosylated lysosomal membrane protein isoform X1

    Conserved Domains (1) summary
    pfam15065
    Location:2200
    NCU-G1; Lysosomal transcription factor, NCU-G1

RNA

  1. XR_426762.3 RNA Sequence

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