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HRH3 histamine receptor H3 [ Homo sapiens (human) ]

Gene ID: 11255, updated on 7-Jun-2020

Summary

Official Symbol
HRH3provided by HGNC
Official Full Name
histamine receptor H3provided by HGNC
Primary source
HGNC:HGNC:5184
See related
Ensembl:ENSG00000101180 MIM:604525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH3R; GPCR97
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 2.9), testis (RPKM 0.2) and 2 other tissues See more
Orthologs

Genomic context

See HRH3 in Genome Data Viewer
Location:
20q13.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (62213845..62220278, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60790017..60795323, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene mitochondrial ribosome associated GTPase 2 Neighboring gene uncharacterized LOC105369209 Neighboring gene oxysterol binding protein like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histamine receptor activity IEA
Inferred from Electronic Annotation
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of glutamate secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of serotonin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of norepinephrine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
histamine H3 receptor
Names
G protein-coupled receptor 97
H3R

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007232.3NP_009163.2  histamine H3 receptor

    See identical proteins and their annotated locations for NP_009163.2

    Status: VALIDATED

    Source sequence(s)
    AL078633
    Consensus CDS
    CCDS13493.1
    UniProtKB/Swiss-Prot
    Q9Y5N1
    Related
    ENSP00000342560.5, ENST00000340177.10
    Conserved Domains (1) summary
    pfam00001
    Location:51412
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    62213845..62220278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260266.3XP_005260323.1  histamine H3 receptor isoform X1

    See identical proteins and their annotated locations for XP_005260323.1

    UniProtKB/Swiss-Prot
    Q9Y5N1
    Related
    ENSP00000321482.7, ENST00000317393.10
    Conserved Domains (1) summary
    pfam00001
    Location:51412
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_017027623.1XP_016883112.1  histamine H3 receptor isoform X2

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