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Hrh3 histamine receptor H3 [ Mus musculus (house mouse) ]

Gene ID: 99296, updated on 6-Jun-2024

Summary

Official Symbol
Hrh3provided by MGI
Official Full Name
histamine receptor H3provided by MGI
Primary source
MGI:MGI:2139279
See related
Ensembl:ENSMUSG00000039059 AllianceGenome:MGI:2139279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H3R; Eae8; HH3R
Summary
Predicted to enable G protein-coupled amine receptor activity; amine binding activity; and heterocyclic compound binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in myelin sheath; neuron projection; and plasma membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in brain. Orthologous to human HRH3 (histamine receptor H3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 17.2), cortex adult (RPKM 16.0) and 8 other tissues See more
Orthologs
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Genomic context

See Hrh3 in Genome Data Viewer
Location:
2 H4; 2 102.62 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179741258..179746264, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180099465..180104484, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene mitochondrial ribosome associated GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:179830439-179830640 Neighboring gene predicted gene, 46782 Neighboring gene STARR-positive B cell enhancer ABC_E332 Neighboring gene oxysterol binding protein-like 2 Neighboring gene predicted gene, 29886

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
susceptibility to experimental allergic encephalomyelitis 8
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables amine binding ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cAMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in drinking behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of serotonin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
histamine H3 receptor
Names
experimental allergic encephalomyelitis susceptibility 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409451.1NP_001396380.1  histamine H3 receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    Q3U1A2
  2. NM_001409452.1NP_001396381.1  histamine H3 receptor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    Q3USH0
  3. NM_001409453.1NP_001396382.1  histamine H3 receptor isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    B3Y5Z8
  4. NM_001409454.1NP_001396383.1  histamine H3 receptor isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    Q3USH0
  5. NM_001409455.1NP_001396384.1  histamine H3 receptor isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    Q3U1A2
  6. NM_001409456.1NP_001396385.1  histamine H3 receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    Q3U1A2
  7. NM_001409457.1NP_001396386.1  histamine H3 receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    Q3U1A2
  8. NM_001409458.1NP_001396387.1  histamine H3 receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672130
    UniProtKB/TrEMBL
    Q3U1A2
  9. NM_133849.4NP_598610.1  histamine H3 receptor isoform 1

    See identical proteins and their annotated locations for NP_598610.1

    Status: VALIDATED

    Source sequence(s)
    AL672130
    Consensus CDS
    CCDS17169.1
    UniProtKB/Swiss-Prot
    P58406
    UniProtKB/TrEMBL
    B3Y5Z8, Q540P3
    Related
    ENSMUSP00000049963.4, ENSMUST00000056480.10
    Conserved Domains (1) summary
    pfam00001
    Location:51412
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179741258..179746264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)