Hrh3 histamine receptor H3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hrh3provided by MGI
Official Full Name: histamine receptor H3provided by MGI
Primary source: MGI:MGI:2139279
See related: Ensembl:ENSMUSG00000039059 AllianceGenome:MGI:2139279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H3R; Eae8; HH3R
Summary: Predicted to enable G protein-coupled amine receptor activity; amine binding activity; and heterocyclic compound binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in myelin sheath; neuron projection; and plasma membrane. Predicted to be active in dendrite and synapse. Predicted to be integral component of plasma membrane. Is expressed in brain. Orthologous to human HRH3 (histamine receptor H3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 17.2), cortex adult (RPKM 16.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 102.62 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (179741258..179746293, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180099465..180104484, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine H3 receptor.
Title: The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine H(3) receptor.
Study shows that striatal signaling is regulated by the H3R histamine receptor in a mouse model of tic pathophysiology. observations support the hypothesis that constitutive activity of upregulated H3R receptors in the histidine decarboxylase-KO model mediates the observed alterations in baseline medium spiny neuron signaling.
Title: Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology.
The H3 receptor in the dorsal striatum is a contributor to repetitive behavioral pathology.
Title: Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders.
H3R activation with the agonist R-(-)-alpha-methylhistamine to produce a unique time- and cell type-dependent profile of molecular signaling events in the striatum.
Title: The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons.
H3R is an important regulator of sensorimotor gating, and the lack of H3R significantly modifies striatal dopaminergic
Title: Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum.
Data show that knockout of histamine receptor H3 (Hrh3 receptor) caused a substantial reduction of free-running activity rhythm amplitude.
Title: On the Role of Histamine Receptors in the Regulation of Circadian Rhythms.
These results suggest that H3 receptor may participate in the maintenance of the relaxed state and prevention of over-contraction in mature differentiated myotubes.
Title: Activation of histamine H3 receptor decreased cytoplasmic Ca(2+) imaging during electrical stimulation in the skeletal myotubes.
Histamine H3 receptors were expressed in mouse beta cells and could play a role in insulin secretion and, possibly, beta cell proliferation.
Title: The expression and function of histamine H₃ receptors in pancreatic beta cells.
Hrh3 polymorphisms between EAE-susceptible and resistant SJL and B10.S mice
Title: Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility.
Greater slow wave sleep increases are found in histamine H3 knock-out mice compared to wild-type mice, consistent with enhanced histamine transmission.
Title: Enhanced histaminergic neurotransmission and sleep-wake alterations, a study in histamine H3-receptor knock-out mice.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Associated conditions

Description	Tests
susceptibility to experimental allergic encephalomyelitis 8 GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
QTL (1) 1 citation
Not Applicable (1) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

AW049250 (e-PCR)
- UniSTS:178791

NoName (e-PCR)
- UniSTS:495075

Homology

Homologs of the Hrh3 gene: The Hrh3 gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 340 organisms have orthologs with human gene Hrh3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables amine binding	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables histamine receptor activity	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cAMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cognition	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamate secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of serotonin secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of serotonin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter levels	IEA Inferred from Electronic Annotation more info
involved_in regulation of norepinephrine secretion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of norepinephrine secretion	ISO Inferred from Sequence Orthology more info
involved_in response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: histamine H3 receptor

Names: experimental allergic encephalomyelitis susceptibility 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409451.1 → NP_001396380.1 histamine H3 receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL672130
NM_001409452.1 → NP_001396381.1 histamine H3 receptor isoform 3

Status: VALIDATED

Source sequence(s)

AL672130
NM_001409453.1 → NP_001396382.1 histamine H3 receptor isoform 4

Status: VALIDATED

Source sequence(s)

AL672130
NM_001409454.1 → NP_001396383.1 histamine H3 receptor isoform 5

Status: VALIDATED

Source sequence(s)

AL672130
NM_001409455.1 → NP_001396384.1 histamine H3 receptor isoform 6

Status: VALIDATED

Source sequence(s)

AL672130
NM_001409456.1 → NP_001396385.1 histamine H3 receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL672130
NM_001409457.1 → NP_001396386.1 histamine H3 receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL672130
NM_001409458.1 → NP_001396387.1 histamine H3 receptor isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL672130
NM_133849.4 → NP_598610.1 histamine H3 receptor isoform 1

See identical proteins and their annotated locations for NP_598610.1

Status: VALIDATED

Source sequence(s)

AL672130

Consensus CDS

CCDS17169.1

UniProtKB/Swiss-Prot

P58406

UniProtKB/TrEMBL

Q3USH0, Q540P3

Related

ENSMUSP00000049963.4, ENSMUST00000056480.10

Conserved Domains (1) summary

pfam00001
Location:51 → 412

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

179741258..179746293 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162761.1 → XP_036018654.1 histamine H3 receptor isoform X1

Conserved Domains (2) summary

cd14964
Location:40 → 70

7tm_GPCRs; TM helix 5 [structural motif]

cl28897
Location:1 → 268

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017319357.3 → XP_017174846.1 histamine H3 receptor isoform X1

Conserved Domains (2) summary

cd14964
Location:40 → 70

7tm_GPCRs; TM helix 5 [structural motif]

cl28897
Location:1 → 268

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily