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RPL35 ribosomal protein L35 [ Homo sapiens (human) ]

Gene ID: 11224, updated on 5-Jul-2020

Summary

Official Symbol
RPL35provided by HGNC
Official Full Name
ribosomal protein L35provided by HGNC
Primary source
HGNC:HGNC:10344
See related
Ensembl:ENSG00000136942 MIM:618315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L35; DBA19
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 754.0), bone marrow (RPKM 543.3) and 25 other tissues See more
Orthologs

Genomic context

See RPL35 in Genome Data Viewer
Location:
9q33.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124857883..124861957, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127620158..127624240, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987126 Neighboring gene olfactomedin like 2A Neighboring gene WD repeat domain 38 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene golgin A1 Neighboring gene RNA, U4 small nuclear 82, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL35 as demonstrated by proximity dependent biotinylation proteomics PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L35 (RPL35) at amino acid residues 57-58 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
cytosolic large ribosomal subunit HDA PubMed 
cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleolus TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
60S ribosomal protein L35
Names
large ribosomal subunit protein uL29

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007209.4NP_009140.1  60S ribosomal protein L35

    See identical proteins and their annotated locations for NP_009140.1

    Status: REVIEWED

    Source sequence(s)
    BM854016, CR996819, U12465
    Consensus CDS
    CCDS6858.1
    UniProtKB/Swiss-Prot
    P42766
    Related
    ENSP00000259469.4, ENST00000348462.6
    Conserved Domains (1) summary
    pfam00831
    Location:863
    Ribosomal_L29; Ribosomal L29 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    124857883..124861957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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