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RPL35 ribosomal protein L35 [ Homo sapiens (human) ]

Gene ID: 11224, updated on 11-Jun-2021


Official Symbol
RPL35provided by HGNC
Official Full Name
ribosomal protein L35provided by HGNC
Primary source
See related
Ensembl:ENSG00000136942 MIM:618315
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L35; DBA19
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Ubiquitous expression in ovary (RPKM 754.0), bone marrow (RPKM 543.3) and 25 other tissues See more
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Genomic context

See RPL35 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124857883..124861957, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127620162..127624236, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987126 Neighboring gene olfactomedin like 2A Neighboring gene WD repeat domain 38 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene golgin A1 Neighboring gene RNA, U4 small nuclear 82, pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL35 as demonstrated by proximity dependent biotinylation proteomics PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human 60S ribosomal protein L35 (RPL35) at amino acid residues 57-58 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
located_in membrane HDA PubMed 
located_in nucleolus TAS
Traceable Author Statement
more info

General protein information

Preferred Names
60S ribosomal protein L35
large ribosomal subunit protein uL29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007209.4NP_009140.1  60S ribosomal protein L35

    See identical proteins and their annotated locations for NP_009140.1

    Status: REVIEWED

    Source sequence(s)
    BM854016, CR996819, U12465
    Consensus CDS
    ENSP00000259469.4, ENST00000348462.6
    Conserved Domains (1) summary
    Ribosomal_L29; Ribosomal L29 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    124857883..124861957 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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