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CHKB choline kinase beta [ Homo sapiens (human) ]

Gene ID: 1120, updated on 8-Dec-2018

Summary

Official Symbol
CHKBprovided by HGNC
Official Full Name
choline kinase betaprovided by HGNC
Primary source
HGNC:HGNC:1938
See related
Ensembl:ENSG00000100288 MIM:612395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK; EK; CKB; EKB; CHKL; CHETK; CKEKB; MDCMC
Summary
Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]
Expression
Ubiquitous expression in spleen (RPKM 35.8), lymph node (RPKM 28.9) and 25 other tissues See more
Orthologs

Genomic context

See CHKB in Genome Data Viewer
Location:
22q13.33
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (50578958..50582999, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (51017387..51021428, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 3 Neighboring gene uncharacterized LOC107985568 Neighboring gene CHKB-CPT1B readthrough (NMD candidate) Neighboring gene carnitine palmitoyltransferase 1B Neighboring gene CHKB divergent transcript Neighboring gene mitogen-activated protein kinase 8 interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough CHKB-CPT1B

Readthrough gene: CHKB-CPT1B, Included gene: CPT1B

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
choline kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
choline kinase activity TAS
Traceable Author Statement
more info
 
ethanolamine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ethanolamine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylethanolamine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
choline/ethanolamine kinase
Names
choline kinase-like protein
ethanolamine kinase beta
NP_005189.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029213.1 RefSeqGene

    Range
    5001..9042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_855

mRNA and Protein(s)

  1. NM_005198.4NP_005189.2  choline/ethanolamine kinase

    See identical proteins and their annotated locations for NP_005189.2

    Status: REVIEWED

    Source sequence(s)
    AB029886, BE676287, DB106393
    Consensus CDS
    CCDS14099.1
    UniProtKB/Swiss-Prot
    Q9Y259
    UniProtKB/TrEMBL
    A0A024R4X4
    Related
    ENSP00000384400.2, ENST00000406938.2
    Conserved Domains (2) summary
    PLN02236
    Location:57388
    PLN02236; choline kinase
    cd05156
    Location:69385
    ChoK_euk; Euykaryotic Choline Kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    50578958..50582999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152253.1: Suppressed sequence

    Description
    NM_152253.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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