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CELF3 CUGBP Elav-like family member 3 [ Homo sapiens (human) ]

Gene ID: 11189, updated on 2-Mar-2021

Summary

Official Symbol
CELF3provided by HGNC
Official Full Name
CUGBP Elav-like family member 3provided by HGNC
Primary source
HGNC:HGNC:11967
See related
Ensembl:ENSG00000159409 MIM:612678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAGH4; ERDA4; ETR-1; TNRC4; BRUNOL1
Summary
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Expression
Biased expression in brain (RPKM 11.4), adrenal (RPKM 3.2) and 4 other tissues See more
Orthologs
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Genomic context

See CELF3 in Genome Data Viewer
Location:
1q21.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151696652..151716821, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151672534..151689279, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.8572 Neighboring gene sorting nexin 27 Neighboring gene RNA, U6 small nuclear 1062, pseudogene Neighboring gene regulatory subunit of type II PKA R-subunit domain containing 1 Neighboring gene RNA, U6 small nuclear 662, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC57297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pre-mRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA splice site selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CUGBP Elav-like family member 3
Names
CAG repeat domain
CAG repeat protein 4
CUG-BP- and ETR-3-like factor 3
ELAV-type RNA-binding protein 1
RNA-binding protein BRUNOL-1
bruno-like protein 1
expanded repeat domain protein CAG/CTG 4
expanded repeat domain, CAG/CTG 4
trinucleotide repeat containing 4
trinucleotide repeat-containing gene 4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172648.4NP_001166119.1  CUGBP Elav-like family member 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL589765, KF455029
    UniProtKB/TrEMBL
    Q59G45
    Conserved Domains (3) summary
    cd12635
    Location:47127
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:329407
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl17169
    Location:241
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001172649.4NP_001166120.1  CUGBP Elav-like family member 3 isoform 3

    See identical proteins and their annotated locations for NP_001166120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL589765, KF455029
    Consensus CDS
    CCDS53367.1
    UniProtKB/Swiss-Prot
    Q5SZQ8
    Related
    ENSP00000290585.4, ENST00000290585.8
    Conserved Domains (3) summary
    cd12632
    Location:288
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:326404
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  3. NM_001291106.2NP_001278035.1  CUGBP Elav-like family member 3 isoform 4

    See identical proteins and their annotated locations for NP_001278035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AL589765, KF455029
    UniProtKB/Swiss-Prot
    Q5SZQ8
    Conserved Domains (4) summary
    PRK12323
    Location:214350
    PRK12323; DNA polymerase III subunit gamma/tau
    cd12639
    Location:375453
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12632
    Location:288
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  4. NM_001291107.2NP_001278036.1  CUGBP Elav-like family member 3 isoform 5

    See identical proteins and their annotated locations for NP_001278036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AL589765, KF455029
    UniProtKB/Swiss-Prot
    Q5SZQ8
    Conserved Domains (4) summary
    PRK12323
    Location:213350
    PRK12323; DNA polymerase III subunit gamma/tau
    cd12632
    Location:288
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:93173
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:375453
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  5. NM_007185.7NP_009116.3  CUGBP Elav-like family member 3 isoform 1

    See identical proteins and their annotated locations for NP_009116.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL589765, KF455029
    Consensus CDS
    CCDS1002.1
    UniProtKB/Swiss-Prot
    Q5SZQ8
    Related
    ENSP00000290583.4, ENST00000290583.9
    Conserved Domains (4) summary
    PRK12323
    Location:214351
    PRK12323; DNA polymerase III subunit gamma/tau
    cd12639
    Location:376454
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12632
    Location:288
    RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151696652..151716821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711141.3XP_006711204.1  CUGBP Elav-like family member 3 isoform X4

    See identical proteins and their annotated locations for XP_006711204.1

    Related
    ENSP00000402503.1, ENST00000420342.1
    Conserved Domains (3) summary
    cd12639
    Location:299377
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:2384
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1797
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  2. XM_006711139.3XP_006711202.1  CUGBP Elav-like family member 3 isoform X2

    See identical proteins and their annotated locations for XP_006711202.1

    Conserved Domains (3) summary
    cd12639
    Location:300378
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:21385
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  3. XM_024452761.1XP_024308529.1  CUGBP Elav-like family member 3 isoform X4

    Conserved Domains (3) summary
    cd12639
    Location:299377
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:2384
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1797
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  4. XM_024452759.1XP_024308527.1  CUGBP Elav-like family member 3 isoform X2

    Conserved Domains (3) summary
    cd12639
    Location:300378
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:21385
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  5. XM_024452758.1XP_024308526.1  CUGBP Elav-like family member 3 isoform X2

    Conserved Domains (3) summary
    cd12639
    Location:300378
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:21385
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  6. XM_024452760.1XP_024308528.1  CUGBP Elav-like family member 3 isoform X3

    Conserved Domains (3) summary
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:299377
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cl25887
    Location:21384
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  7. XM_011509111.3XP_011507413.1  CUGBP Elav-like family member 3 isoform X1

    Conserved Domains (4) summary
    cd12632
    Location:288
    RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12635
    Location:94174
    RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    cd12639
    Location:325403
    RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:9414
    ELAV_HUD_SF; ELAV/HuD family splicing factor
  8. XM_011509114.3XP_011507416.1  CUGBP Elav-like family member 3 isoform X4

    See identical proteins and their annotated locations for XP_011507416.1

    Conserved Domains (3) summary
    cd12639
    Location:299377
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:2384
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1797
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
  9. XM_011509112.3XP_011507414.1  CUGBP Elav-like family member 3 isoform X2

    See identical proteins and their annotated locations for XP_011507414.1

    Conserved Domains (3) summary
    cd12639
    Location:300378
    RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    TIGR01661
    Location:21385
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cd12635
    Location:1898
    RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
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